| Type | Description |
|---|---|
| Definition | titin |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 12:29:00 | Titin-truncating variants lead to impaired autophagy and mitochondrial function in the heart. These changes not only provide molecular mechanisms that underlie Titin-truncating variants-associated ventricular remodeling but also offer potential targets for its intervention. | 30715350 |
| 2019-02-09 10:31:00 | In the context of pressure overload, Z-disc TTNtv is associated with cardiac fibrosis, diastolic dysfunction, and capillary rarefaction in the absence of overt systolic dysfunction. | 30063764 |
| 2018-12-01 11:25:00 | These findings reveal a major signal transduction pathway for insulin-induced titin alternative splicing, and place RBM20 in a central position in the pathway, which is consistent with the reputed role of RBM20 in titin alternative splicing. | 28676430 |
| 2017-09-09 11:55:00 | Titin-truncating variant is associated with dilated cardiomyopathy. | 27869827 |
| 2016-07-30 10:11:00 | sarcomere stretch-induced simultaneous structural rearrangements within both thin and thick filaments that correlate with titin strain and myofilament length-dependent activation | 26858417 |
| Type | IDs |
|---|---|
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
XP_017447817.1,
XP_017456475.1
|
| Others |
UniGene:
Rn.4008,
Rn.232176,
Rn.232712,
Rn.232713,
Rn.232714,
Rn.232729
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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