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840 CASP7

840

CASP7

caspase 7

protein-coding

Homo sapiens

基因描述

Type Description
Definition caspase 7

研究结论

Date Results Publications
2020-12-19 13:38:00 Association of genetic polymorphisms in CASP7 with risk of ischaemic stroke. 31819117
2020-10-10 12:59:00 Endocrine resistant breast cancer cells with loss of ERalpha expression retain proliferative ability by reducing caspase7-mediated HDAC3 cleavage. 31701491
2020-05-09 10:29:00 Study identified associations in people of European ancestry with variants in 12 novel loci. The most robust finding is a rare CASP7 missense variant which improved when combined with results from stage 2 data sets. This study demonstrated that an enriched case design can strengthen genetic signals, thus allowing detection of associations that would otherwise be missed in a traditional case-control study. 30503768
2020-05-02 10:52:00 Thus, activation of effector caspase-3 or -7 sets off explosive feedback amplification of upstream apoptotic events, which is a key feature of apoptotic signaling essential for efficient apoptotic cell death. 31392262
2020-04-04 11:13:00 4 lysine residues (K38KKK) located in the N-terminal domain of caspase-7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1. 31586028

名称对应

Type IDs
Synonymous CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3
Gene
UniProtKB-ID: CASP7_HUMAN, B4DWA2_HUMAN, A0A0A0MRL7_HUMAN
UniprotKB: P55210, B4DWA2, A0A0A0MRL7
UniParc: UPI000003AEFD, UPI00017A7BC7, UPI000002AB98, UPI000002AB99, UPI000264F484, UPI00017A827C
EMBL: U67206, BC015799, AB451281, U37448, U67319, BT006683, U40281, U39613, AK301437, AL627395, AK298964, U67320, AL592546, U37449, AB451413, CH471066
Ensembl: ENSG00000165806
KO: hsa:840
Nucleutide sequences
EMBL-CDS: EAW49498.1, AAC50346.1, EAW49495.1, AAC50304.1, AAC51152.1, AAC50352.1, BAG70095.1, EAW49497.1, EAW49496.1, EAW49494.1, AAC51153.1, AAF21460.1, BAG61059.1, AAP35329.1, AAC50303.1, AAH15799.1, BAG70227.1, BAG62964.1
Ensembl_TRS: ENST00000345633, ENST00000614447, ENST00000621607, ENST00000369315, ENST00000369331, ENST00000452490, ENST00000621345, ENST00000369318, ENST00000369321
Protein sequencees
Ensembl_PRO: ENSP00000298701, ENSP00000358324, ENSP00000398107, ENSP00000478999, ENSP00000358321, ENSP00000358337, ENSP00000480584, ENSP00000478285, ENSP00000358327
RefSeq: XP_006718080.1, NP_203125.1, XP_011538562.1, NP_001253985.1, NP_001218.1, NP_001307840.1, NP_001253987.1, NP_203126.1, NP_203124.1, XP_016872252.1, NP_001253986.1, XP_016872253.1
Others
UniRef100: UniRef100_P55210, UniRef100_A0A0A0MRL7, UniRef100_B4DWA2
UniRef90: UniRef90_A0A0A0MRL7, UniRef90_P55210
UniRef50: UniRef50_P55210
UniGene: Hs.9216
CCDS: CCDS7582.1, CCDS7581.1, CCDS58096.1, CCDS7580.1

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研究热度

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