| Type | Description |
|---|---|
| Definition | regenerating family member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:02:00 | A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/beta-catenin signaling. | 31605540 |
| 2020-03-14 12:23:00 | The correlation of CDX2 with Reg IV expression was demonstrated in ovarian mucinous carcinoma. Reg IV expression was enhanced by transfection of CDX2 and was suppressed by inhibition of CDX2 expression. OMC-3 cells with ectopically overexpressed CDX2 showed enhanced apoptosis and sensitivity to 5-FU. | 31659102 |
| 2019-08-31 12:10:00 | REG4 plays an important role in KRAS-driven lung cancer pathogenesis and is a novel biomarker of lung adenocarcinoma subtype. Future studies are required to clarify the underlying mechanisms of REG4 in the division and proliferation of KC tumors and its potential therapeutic value. | 31428934 |
| 2018-12-22 11:54:00 | Our study demonstrated that Reg IV positively regulates the expression of SOX9 and is involved in tumor cell invasion and migration in gastric cancer. | 29587675 |
| 2018-04-28 11:15:00 | Reg4 inhibited apoptosis through regulating MAPK/Erk/Bim signaling pathway and thereby enhanced the resistance of gastric cancer to 5-Fluorouracil. | 28759561 |
| Type | IDs |
|---|---|
| Synonymous | GISP, REG-IV, RELP |
| Gene |
UniProtKB-ID:
REG4_HUMAN
UniprotKB:
Q9BYZ8
UniParc:
UPI000003EE44,
UPI0000072760
EMBL:
AY126671,
AF345934,
AY126670,
AY007243,
BC017089,
AY126672,
AL359752,
AF254415
Ensembl:
ENSG00000134193
KO:
hsa:83998
|
| Nucleutide sequences |
EMBL-CDS:
AAM95599.1,
AAM95600.1,
AAG02562.1,
AAH17089.1,
AAM95598.1,
AAK59869.1,
AAK48435.1
Ensembl_TRS:
ENST00000256585,
ENST00000354219,
ENST00000369401
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000346158,
ENSP00000256585,
ENSP00000358409
RefSeq:
NP_001152825.1,
NP_001152824.1,
NP_114433.1
|
| Others |
UniRef100:
UniRef100_Q9BYZ8
UniRef90:
UniRef90_Q9BYZ8
UniRef50:
UniRef50_Q9BYZ8
UniGene:
Hs.660883
CCDS:
CCDS53354.1,
CCDS906.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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