| Type | Description |
|---|---|
| Definition | SprT-like N-terminal domain |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:55:00 | A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. | 33348378 |
| 2020-10-24 14:12:00 | DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease. | 32853547 |
| 2020-07-04 12:41:00 | TEX264 recognises both unmodified and SUMO1-modifed TOP1 and initiates TOP1cc repair by recruiting p97 and SPRTN. | 32152270 |
| 2020-05-02 12:03:00 | the ZBD contributes to the ssDNA specificity of SPRTN, restricts the access of globular substrates, and positions DPCs, which may need to be partially unfolded, for optimal cleavage. | 30893605 |
| 2017-11-26 00:32:00 | e show that SPRTN is a DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)- a function that had only been attributed to the metalloprotease Wss1 in budding yeast. We provide genetic evidence that SPRTN and Wss1 function distinctly in vivo to resolve DPCs | 27852435 |
| Type | IDs |
|---|---|
| Synonymous | C1orf124, DVC1, PRO4323, spartan |
| Gene |
UniProtKB-ID:
SPRTN_HUMAN,
A0A024R3U2_HUMAN
UniprotKB:
Q9H040,
A0A024R3U2
UniParc:
UPI000004C614,
UPI0000371370,
UPI000006D601
EMBL:
CH471098,
AY358611,
BC015740,
AK027317,
BC068478,
AL117352,
AL512744,
AK027613
Ensembl:
ENSG00000010072
KO:
hsa:83932
|
| Nucleutide sequences |
EMBL-CDS:
AAH68478.1,
BAB55232.1,
BAB55037.1,
AAH15740.1,
EAW69956.1,
CAC21670.1,
AAQ88974.1,
EAW69958.1
Gene_ORFName:
UNQ1880/PRO4323,
hCG_14914
Ensembl_TRS:
ENST00000391858,
ENST00000008440,
ENST00000295050
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000008440,
ENSP00000295050,
ENSP00000375731
RefSeq:
NP_114407.3,
NP_001010984.1,
NP_001248391.1,
XP_006711881.1,
XP_011542591.1
|
| Others |
UniRef100:
UniRef100_Q9H040
UniRef90:
UniRef90_Q9H040
UniRef50:
UniRef50_Q9H040
UniGene:
Hs.554892
CCDS:
CCDS58066.1,
CCDS1594.1,
CCDS31054.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员