| Type | Description |
|---|---|
| Definition | caspase 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:01:00 | Identification of Allosteric Inhibitors against Active Caspase-6. | 30940883 |
| 2019-09-21 12:27:00 | Results show that two Casp6 variants, Casp6-G66R and Casp6-R65W, have less self-processing and exogenous proteolytic activity than Casp6-WT and reveal a novel regulatory area of Casp6 activity. Furthermore, the existence of these Casp6 variants suggests that full Casp6 activity may be dispensable in humans. | 29535332 |
| 2019-04-13 10:09:00 | have identified an exosite on caspase-6 that is critical for protein substrate recognition and turnover and therefore highly relevant for diseases such as cancer in which caspase-6-mediated apoptosis is often disrupted, and in neurodegeneration in which caspase-6 plays a central role. | 30420425 |
| 2018-06-09 11:41:00 | The prodomain region was found to be intrinsically disordered independent of the activation state of caspase-6; however, its complete removal resulted in the protection of the adjacent 26-32 region, suggesting that this region may play a regulatory role. The molecular details of caspase-6 dynamics in solution provide a comprehensive scaffold for strategic design of therapeutic approaches for neurodegenerative disorders. | 28864531 |
| 2018-04-07 11:14:00 | SMSr is a novel and specific substrate of caspase-6, a non-conventional effector caspase implicated in Huntington's and Alzheimer's diseases. | 28659495 |
| Type | IDs |
|---|---|
| Synonymous | MCH2 |
| Gene |
UniProtKB-ID:
CASP6_HUMAN
UniprotKB:
P55212
UniParc:
UPI000002AB97,
UPI00000622E4
EMBL:
BC004460,
U20536,
BC000305,
AY254046,
U20537
Ensembl:
ENSG00000138794
KO:
hsa:839
|
| Nucleutide sequences |
EMBL-CDS:
AAC50169.1,
AAH04460.1,
AAO63494.1,
AAC50168.1,
AAH00305.1
Ensembl_TRS:
ENST00000265164,
ENST00000352981
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000265164,
ENSP00000285333
RefSeq:
NP_116787.1,
NP_001217.2
|
| Others |
UniRef100:
UniRef100_P55212
UniRef90:
UniRef90_P55212
UniRef50:
UniRef50_P55212
UniGene:
Hs.654616
CCDS:
CCDS3685.1,
CCDS3684.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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