| Type | Description |
|---|---|
| Definition | SET domain bifurcated histone lysine methyltransferase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-25 14:10:00 | A number of converging phenotypes outline a stress-responsive mechanism for SETDB1 and SETDB2 activation and subsequent increased tumor survival, providing novel insights into epigenetic biology. [review] | 30850015 |
| 2019-12-14 10:51:00 | Setdb2 regulates macrophage plasticity during normal and pathologic wound repair | 31350176 |
| 2019-10-05 10:22:00 | an oncogenic role for the protein lysine methyltransferase SETDB2 in leukemia pathogenesis. It is overexpressed in pre-BCR(+) ALL and required for their maintenance in vitro and in vivo. SETDB2 expression is maintained as a direct target gene of the chimeric transcription factor E2A-PBX1 in a subset of ALL and suppresses expression of the cell-cycle inhibitor CDKN2C through histone H3K9 tri-methylation | 29694893 |
| 2018-12-22 10:10:00 | SETDB2 transcripts were overexpressed in renal cell tumor subtypes and associated with prognosis. | 29099276 |
| 2018-07-28 11:11:00 | Findings implicate SET domain bifurcated 2 (SETDB2) locus in the longstanding links of handedness with asthma and other atopic diseases. | 29234167 |
| Type | IDs |
|---|---|
| Synonymous | C13orf4, CLLD8, CLLL8, KMT1F |
| Gene |
UniProtKB-ID:
SETB2_HUMAN
UniprotKB:
Q96T68
UniParc:
UPI00001FCDAB,
UPI000013CFF3,
UPI0000F534AE
EMBL:
BC047434,
AL831937,
AL139321,
AL136218,
AF334407,
BC017078
Ensembl:
ENSG00000136169
KO:
hsa:83852
|
| Nucleutide sequences |
EMBL-CDS:
AAH47434.1,
AAK38373.1,
CAH56265.1,
AAH17078.1
Ensembl_TRS:
ENST00000317257,
ENST00000354234
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000326477,
ENSP00000346175
RefSeq:
NP_114121.2,
NP_001153780.1,
NP_001307628.1
|
| Others |
UniRef100:
UniRef100_Q96T68
UniRef90:
UniRef90_Q96T68
UniRef50:
UniRef50_Q96T68
UniGene:
Hs.631789
CCDS:
CCDS53868.1,
CCDS9417.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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