| Type | Description |
|---|---|
| Definition | tyrosine kinase, non-receptor, 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 11:33:00 | TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut. | 30320600 |
| 2014-04-05 10:57:00 | The activated TNK1 potentiates signaling through dual phosphorylation of at tyrosine 701 and serine 727 amino acid positions. | 24449862 |
| 2010-01-21 00:00:00 | Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity | 18974114 |
| 2010-01-21 00:00:00 | cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter | 19481140 |
| 2010-01-21 00:00:00 | data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity | 12789265 |
| Type | IDs |
|---|---|
| Synonymous | Kos1, Tnk1a, Tnk1b |
| Gene |
UniProtKB-ID:
TNK1_MOUSE,
Q3TJU8_MOUSE
UniprotKB:
Q99ML2,
Q3TJU8
UniParc:
UPI0000020B94,
UPI00005B2325,
UPI0000026004
EMBL:
AK167292,
AK033440,
AF307745,
BC055303,
AF307746,
AF332512,
BC029623
Ensembl:
ENSMUSG00000001583
KO:
mmu:83813
|
| Nucleutide sequences |
EMBL-CDS:
AAK35164.1,
AAL09413.1,
BAC28288.1,
AAL09412.1,
AAH55303.1,
AAH29623.1,
BAE39397.1
Ensembl_TRS:
ENSMUST00000001626,
ENSMUST00000108626
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000104266,
ENSMUSP00000001626
RefSeq:
NP_114086.3,
XP_006534617.1
|
| Others |
UniRef100:
UniRef100_Q3TJU8,
UniRef100_Q99ML2
UniRef90:
UniRef90_Q99ML2,
UniRef90_Q99ML2-2
UniRef50:
UniRef50_Q13470,
UniRef50_Q99ML2-2
UniGene:
Mm.28874,
Mm.358793
CCDS:
CCDS24917.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员