例如："NBL1", "4681", "drought"
收藏
83795 KCNK16

83795

KCNK16

potassium two pore domain channel subfamily K member 16

protein-coding

Homo sapiens

基因描述

Type Description
Definition potassium two pore domain channel subfamily K member 16

研究结论

Date Results Publications
2018-05-19 10:44:00 data establish TALK-1 channels as key regulators of beta cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target to reduce ER Ca(2+) handling defects in beta cells during the pathogenesis of diabetes. 28928238
2017-04-29 12:35:00 The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion. 28403169
2016-02-06 12:21:00 These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion. 26239056
2010-01-21 00:00:00 at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas. 12724142

名称对应

Type IDs
Synonymous K2p16.1, TALK-1, TALK1
Gene
UniProtKB-ID: KCNKG_HUMAN
UniprotKB: Q96T55
UniParc: UPI0000127A58, UPI000002A698, UPI00006838F1, UPI00015E05D7
EMBL: CH471081, AF358909, AL136087, AY253147, AY253145, AY253146, BC111860, EU978943
Ensembl: ENSG00000095981
KO: hsa:83795
Nucleutide sequences
EMBL-CDS: ACH86102.1, EAX03985.1, AAP82866.1, AAI11861.1, AAP82868.1, AAP82867.1, EAX03982.1, AAK49532.1, EAX03984.1
Ensembl_TRS: ENST00000373229, ENST00000373227, ENST00000425054, ENST00000437525
Protein sequencees
Ensembl_PRO: ENSP00000362326, ENSP00000391498, ENSP00000362324, ENSP00000415375
RefSeq: NP_001350713.1, NP_115491.1, NP_001128577.1, XP_016866835.1, NP_001128578.1, NP_001128579.1
Others
UniRef100: UniRef100_Q96T55
UniRef90: UniRef90_Q96T55
UniRef50: UniRef50_Q96T55
UniGene: Hs.287765
CCDS: CCDS4843.1, CCDS47421.1, CCDS47422.1, CCDS47420.1

全选

{{proteinIndex+1}}		 mRNA Protein UniprotKB Description
Refseq {{protein.nucleotideVersion}}

Ensembl: {{protein.nucleotideEnsembl}}

{{protein.proteinVersion}}

Ensembl: {{protein.proteinEnsembl}}

{{uniprot}}
Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}
Location ( {{protein.positionStart}}..{{protein.positionEnd}} )

暂无数据

研究热度

热点单位
排名 科研单位 文献
{{affIndex+1}}

{{aff.value}}

 {{aff.size}}

目前还没有研究热点单位

热点人员
排名 研究人员 文献
{{authorIndex+1}}

{{author.value}}

 {{author.size}}

目前还没有研究热点人员

© 2017 biocloud.net版权所有 ICP证：京10042835号