| Type | Description |
|---|---|
| Definition | taste receptor, type 1, member 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 10:55:00 | Using T1R2-knock out (KO) mice authors evaluated the role of STRs in the regulation of glucose absorption in vivo and in intact intestinal preparations ex vivo. | 30201274 |
| 2018-12-22 11:22:00 | our platform provides in depth analysis of new sweeteners either alone or in competition and/or inhibition studies to fully understand the structure/functional role of ATD region of T1R2 that transpires in the initial binding event prior to sweet taste response. | 30282936 |
| 2018-12-22 10:13:00 | Data suggest that Tas1r2 and Tas1r3 are involved in regulation of Glp1 secretion in enteroendocrine cells; 3DG (3-deoxyglucosone) attenuates high glucose-stimulated Glp1 secretion by antagonizing Tas1r2/Tas1r3 subunits and downstream cAMP signaling. (Tas1r2 = sweet taste receptor subunit Tas1r2; Tas1r3 = sweet taste receptor subunit Tas1r3; Glp1 = glucagon-like peptide-1) | 29277113 |
| 2018-06-16 11:24:00 | Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk during osteoclast differentiation. (Ctsk = cathepsin K) | 29019082 |
| 2017-10-21 12:24:00 | mice lacking T1R2 + T1R3 and controls were tested in a taste discrimination task to determine whether maltodextrins are 1) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3. | 28768658 |
| Type | IDs |
|---|---|
| Synonymous | Gpr71, T1r2, TR2 |
| Gene |
UniProtKB-ID:
TS1R2_MOUSE
UniprotKB:
Q925I4
UniParc:
UPI00000291AC
EMBL:
AL831790,
AF337041,
AY032623
Ensembl:
ENSMUSG00000028738
KO:
mmu:83770
|
| Nucleutide sequences |
EMBL-CDS:
AAK39438.1,
AAK51604.1
Ensembl_TRS:
ENSMUST00000030510
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030510
RefSeq:
NP_114079.1
|
| Others |
UniRef100:
UniRef100_Q925I4
UniRef90:
UniRef90_Q925I4
UniRef50:
UniRef50_Q8TE23
UniGene:
Mm.190612
CCDS:
CCDS18849.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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