| Type | Description |
|---|---|
| Definition | wolframin ER transmembrane glycoprotein |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:27:00 | Calpain inhibitor and ibudilast rescue beta cell functions in a cellular model of Wolfram syndrome. | 32632005 |
| 2019-06-15 12:16:00 | Study presents a novel rat model of Wolfram syndrome (WS) in which exon 5 of the Wfs1 gene is deleted, resulting in a loss of 27 amino acids from the WFS1 protein sequence. The severity of the phenotype in this Wfs1-mutant rat more closely mimics the human condition such as insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. | 28860598 |
| 2010-04-12 12:23:00 | a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes. | 20160352 |
| 2010-02-08 11:36:00 | WFS1 may be involved in some aspects of rat pancreatic development | 19916172 |
| 2010-01-21 00:00:00 | Role of increased expression of the wolframin gene in the regulation of emotional behavior. | 11958857 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q9JLT5_RAT
UniprotKB:
Q9JLT5
UniParc:
UPI0000050259
EMBL:
AF136378
KO:
rno:83725
|
| Nucleutide sequences |
EMBL-CDS:
AAF61423.1
|
| Protein sequencees |
RefSeq:
NP_114011.1
|
| Others |
UniRef100:
UniRef100_Q9JLT5
UniRef90:
UniRef90_P56695
UniRef50:
UniRef50_O76024
UniGene:
Rn.229139
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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