Plk2 - polo-like kinase 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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83722 Plk2

基因描述

Type	Description
Definition	polo-like kinase 2

研究结论

Date	Results	Publications
2020-06-13 13:05:00	Overexpression of PLK2 reverses the effect of upregulation of miR-27a on synovial angiogenesis and chondrocyte injury in KOA rats. Our study suggests that upregulation of miR-27a inhibits synovial angiogenesis and chondrocyte apoptosis in KOA rats through the inhibition of PLK2.	31134620
2018-06-23 11:09:00	Plk2 acts as coordinator of cell proliferation and early lineage commitment in cardiac progenitor cells downstream of Yes-associated protein 1.	29066438
2017-06-24 10:44:00	PLK2, functional kinase and polo-box domains were required for interaction with PFV Gag. Fluorescently-tagged PFV Gag, through its chromatin tethering function, selectively relocalized ectopically expressed eGFP-tagged PLK proteins to mitotic chromosomes i	27579920
2014-06-28 12:42:00	Prenatal stress increased Snk Polo-like kinase 2 in thr hippocampus of the offspring at adulthood in rats	23850969
2013-12-07 11:27:00	In a rat model of Parkinson disease, PLK2 overexpression reduces alpha-syn levels and suppresses alpha-syn-induced toxicity and motor deficits.	23983262

名称对应

Type	IDs
Synonymous	Snk
Gene	UniProtKB-ID: PLK2_RAT UniprotKB: Q9R012 UniParc: UPI0000135B36 EMBL: BC070878, AF136583 Ensembl: ENSRNOG00000011951 KO: rno:83722
Nucleutide sequences	EMBL-CDS: AAH70878.1, AAF08366.1 Ensembl_TRS: ENSRNOT00000016768
Protein sequencees	Ensembl_PRO: ENSRNOP00000016768 RefSeq: NP_114009.1
Others	UniRef100: UniRef100_Q9R012 UniRef90: UniRef90_Q9NYY3 UniRef50: UniRef50_Q9NYY3 UniGene: Rn.12100

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
31134620	Upregulation of microRNA-27a inhibits synovial angiogenesis and chondrocyte apoptosis in knee osteoarthritis rats through the inhibition of PLK2. J. Cell. Physiol. Wenjing Liu , Zhuqing Zha , Haitao Wang	2019-12-01	-
29066438	Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells. J Am Heart Assoc Michika Mochizuki , Vera Lorenz , Robert Ivanek , Giacomo Della Verde , Emanuele Gaudiello , Anna Marsano , Otmar Pfister , Gabriela M Kuster	2017-10-24	-
27908889	MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression. Arterioscler. Thromb. Vasc. Biol. Shanming Deng , Huilan Wang , Chunling Jia , Shoukang Zhu , Xianming Chu , Qi Ma , Jianqin Wei , Emily Chen , Wei Zhu , Conrad J Macon , Dushyantha T Jayaweera , Derek M Dykxhoorn , Chunming Dong	2017-02-01	-
27579920	Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog Irena Zurnic , Sylvia HÃ¼tter , Ute Rzeha , Nicole Stanke , Juliane Reh , Erik MÃ¼llers , Martin V Hamann , Tobias Kern , Gesche K Gerresheim , Fabian Lindel , Erik Serrao , Paul Lesbats , Alan N Engelman , Peter Cherepanov , Dirk Lindemann	2016-08-01	-
26934179	miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction. Stem Cells Lena Pitzler , Markus Auler , Kristina Probst , Christian Frie , Vera Bergmeier , Tatjana Holzer , Daniele Belluoccio , Jocelyn van den Bergen , Julia Etich , Harald Ehlen , Zhigang Zhou , Wolfgang Bielke , Ernst PÃ¶schl , Mats Paulsson , Bent Brachvogel	2016-05-01	-
23850969	Prenatal stress increased Snk Polo-like kinase 2, SCF Î²-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood. Int. J. Dev. Neurosci. Naunchan Chutabhakdikul , Pornprom Surakul	2013-11-01	-
23983262	Polo-like kinase 2 regulates selective autophagic Î±-synuclein clearance and suppresses its toxicity in vivo. Proc. Natl. Acad. Sci. U.S.A. Abid Oueslati , Bernard L Schneider , Patrick Aebischer , Hilal A Lashuel	2013-10-08	Plk2, PLK2, SNCA
23466428	Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei. Toxicol. Appl. Pharmacol. Kent Fitzgerald , Marcelle Bergeron , Christopher Willits , Simeon Bowers , Danielle L Aubele , Erich Goldbach , George Tonn , Daniel Ness , Andrew Olaharski	2013-05-15	Plk2, Plk2, PLK2
23479645	Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures. Proc. Natl. Acad. Sci. U.S.A. Hongyu Sun , Bela Kosaras , Peter M Klein , Frances E Jensen	2013-03-26	Plk2
22854038	Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. Philip W Jordan , Jesse Karppinen , Mary A Handel	2012-11-01	Cdk1, Plk3, H2afx, Plk1, Plk2, Plk4, Sycp1, Sycp3, Rec8, Tex12, Hormad1, Syce2, Hormad2, PLK1, CDK1

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