| Type | Description |
|---|---|
| Definition | caspase 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:54:00 | Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility. | 32484462 |
| 2020-09-05 13:58:00 | Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. | 32581219 |
| 2020-07-18 10:42:00 | GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. | 30321352 |
| 2020-06-27 10:32:00 | Suppressing caspase-4 reduces the cytoplasmic distribution of endogenous TDP-43 in cultured human neural cells. Primate-specific caspase-4-mediated cleavage of TDP-43 accounts for its cytoplasmic mislocalization in the primate brains. | 30810811 |
| 2020-01-04 10:09:00 | Data show that CASP4/caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances graft-versus-host disease (GVHD) severity. | 31492850 |
| Type | IDs |
|---|---|
| Synonymous | ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX |
| Gene |
UniProtKB-ID:
CASP4_HUMAN
UniprotKB:
P49662
UniParc:
UPI00017A8755,
UPI00017A7233,
UPI00000713B7,
UPI000011F190,
UPI000003AEFA
EMBL:
AP001153,
AK057094,
AK304222,
U28014,
Z48810,
U28976,
AP002004,
CH471065,
U28979,
U28978,
BC017839,
AL050391,
AK296081,
U25804,
U28977,
EF636667
Ensembl:
ENSG00000196954
KO:
hsa:837
|
| Nucleutide sequences |
EMBL-CDS:
BAG58837.1,
BAG65094.1,
AAA86890.1,
AAC99852.1,
CAA88750.1,
AAC99851.1,
AAC99853.1,
BAG51861.1,
AAC99854.1,
CAB43686.2,
AAA75171.1,
ABR09278.1,
EAW67052.1,
AAH17839.1,
EAW67051.1,
EAW67050.1,
AAC99850.1
Ensembl_TRS:
ENST00000444739,
ENST00000393150
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000388566,
ENSP00000376857
RefSeq:
XP_011541321.1,
XP_016873886.1,
NP_150649.1,
NP_001216.1
|
| Others |
UniRef100:
UniRef100_P49662
UniRef90:
UniRef90_P49662
UniRef50:
UniRef50_P49662
UniGene:
Hs.138378
CCDS:
CCDS41704.1,
CCDS8327.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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