Kcnj11 - potassium voltage-gated channel subfamily J member 11-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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83535 Kcnj11

基因描述

Type	Description
Definition	potassium voltage-gated channel subfamily J member 11

研究结论

Date	Results	Publications
2020-01-04 11:25:00	Our findings suggest that the NF-kappaB, p38 MAPK, and signal pathways are partially involved in the upregulation of KATP subunits Kir6.2/SUR1 expression induced by Abeta1-42 cytotoxicity in neurons, which supports a potential theoretical basis of targeting these signal pathways in the treatment of Alzheimer's disease.	30868916
2019-09-07 12:32:00	Up-regulation of the KATP channel accelerates repolarization and shortens action potential duration during stress and exercise.	30074836
2018-02-17 11:20:00	Intricate interactions between TMD0, the loop following TMD0, and Kir6.2 near the proposed PIP2 binding site, and where ATP density is observed, suggest SUR1 may contribute to ATP and PIP2 binding to enhance Kir6.2 sensitivity to both.	28092267
2017-12-09 13:39:00	The E23K variant of the KATP channel increased the susceptibility to ventricular arrhythmia under acute ischemia stress.	28082085
2017-10-28 10:49:00	both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations.	28842488

名称对应

Type	IDs
Synonymous	Kir6.2
Gene	UniProtKB-ID: KCJ11_RAT UniprotKB: P70673 UniParc: UPI000012D8AB EMBL: X97041, D86039, U44897, D61687, AB043638 Ensembl: ENSRNOG00000021128 KO: rno:83535
Nucleutide sequences	EMBL-CDS: BAA96239.1, AAB01810.1, BAA23630.1, BAA12971.1, CAA65754.1 Ensembl_TRS: ENSRNOT00000028685
Protein sequencees	Ensembl_PRO: ENSRNOP00000028685 RefSeq: XP_017445269.1, XP_017445271.1, XP_008757643.1, NP_112648.2
Others	UniRef100: UniRef100_P70673 UniRef90: UniRef90_Q14654 UniRef50: UniRef50_Q14654 UniGene: Rn.3985

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Pubmed编号	文献信息	发表日期	相关基因
30868916	AÎ²1-42 increases the expression of neural KATP subunits Kir6.2/SUR1 via the NF-ÎºB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons. Hum Exp Toxicol Y Li , M Ba , Y Du , C Xia , S Tan , K P Ng , G Ma	2019-06-01	-
30074836	Effects of regular exercise on ventricular myocyte biomechanics and K_ATP channel function. Am. J. Physiol. Heart Circ. Physiol. Xinrui Wang , Robert H Fitts	2018-10-01	-
28842488	Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. J Biol Chem Paige E Cooper , Conor McClenaghan , Xingyu Chen , Anna Stary-Weinzinger , Colin G Nichols	2017-10-20	-
28082085	The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats. Int. J. Cardiol. Ying Feng , Jianfang Liu , Menglong Wang , Menglin Liu , Lei Shi , Wenhui Yuan , Jing Ye , Dan Hu , Jun Wan	2017-04-01	-
28092267	Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating. Elife Gregory M Martin , Craig Yoshioka , Emily A Rex , Jonathan F Fay , Qing Xie , Matthew R Whorton , James Z Chen , Show-Ling Shyng	2017-01-16	-
27430376	Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis. Int. J. Mol. Med. Xiaohui Zhang , Xiaohua Zhang , Yiqun Xiong , Chaoying Xu , Xinliang Liu , Jian Lin , Guiping Mu , Shaogang Xu , Wenhe Liu	2016-09-01	-
26591689	Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. J Tradit Chin Med Wei Wang , Jiquan Li , Xiangyu Meng , Yiguo Chen	2015-10-01	-
25236767	Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. Biochem. J. David Lodwick , Richard D Rainbow , Hussein N Rubaiy , Mohammed Al Johi , Geerten W Vuister , Robert I Norman	2014-12-15	Abcc9, Kcnj11
25073062	Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels. J. Mol. Cell. Cardiol. Li Xie , Tao Liang , Youhou Kang , Xianguang Lin , Roozbeh Sobbi , Huanli Xie , Christin Chao , Peter Backx , Zhong-Ping Feng , Show-Ling Shyng , Herbert Y Gaisano	2014-10-01	Abcc9, Kcnj11
24681897	Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. Exp. Physiol. E M Gaber , P Jayaprakash , M A Qureshi , K Parekh , M Oz , T E Adrian , F C Howarth	2014-06-01	-

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