| Type | Description |
|---|---|
| Definition | caspase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-05 12:57:00 | Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface. | 32046398 |
| 2020-09-19 16:22:00 | MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer. | 30816202 |
| 2020-08-01 11:23:00 | With regard to the multifunctional roles of caspase-2 in apoptosis and diverse non-apoptotic processes, the negative regulation of caspase-2 by TRIM25 may have a strong impact on cell survival and drug resistance in colon carcinoma cells. | 31842382 |
| 2020-07-11 10:07:00 | Phosphorylation of caspase-2 by p38 MAPK is essential for regulation involving a caspase-3-mediated cleavage of SREBP2. | 31296846 |
| 2020-06-27 11:04:00 | Results indicate an association between Deltatau314 and dementia in Lewy body disease. Cleavage of tau by Casp2 promotes the mislocalization of tau to dendritic spines leading to a reduction in postsynaptic AMPA receptors and excitatory neurotransmission, which suggests a mechanism of the synaptic dysfunction underlying cognitive impairment in Lewy body disease. | 31362787 |
| Type | IDs |
|---|---|
| Synonymous | CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 |
| Gene |
UniProtKB-ID:
CASP2_HUMAN,
D3DXD9_HUMAN,
A0A0S2Z3H1_HUMAN,
A0A087WYM1_HUMAN
UniprotKB:
P42575,
D3DXD9,
A0A0S2Z3H1,
A0A087WYM1
UniParc:
UPI0000231C98,
UPI0000071E7E,
UPI000020F1E8,
UPI000002AB96,
UPI000011DC0B
EMBL:
AF314174,
AC073342,
AK291274,
BC002427,
U13022,
BT007240,
CR541748,
AY219042,
KU177957,
AB209640,
AF314175,
U13021,
CH471198
Ensembl:
ENSG00000106144
KO:
hsa:835
|
| Nucleutide sequences |
EMBL-CDS:
CAG46548.1,
AAH02427.2,
EAW51867.1,
AAP22346.1,
AAP22348.1,
BAD92877.1,
AAP22349.1,
AAO25653.1,
BAF83963.1,
AAP35904.1,
AAK00299.1,
AAP22347.1,
EAW51870.1,
AAA58959.1,
AAK00300.1,
AAA58960.1,
EAW51863.1,
EAW51862.1,
EAW51860.1,
ALQ33415.1
Gene_ORFName:
hCG_20684
Ensembl_TRS:
ENST00000310447,
ENST00000350623,
ENST00000619992
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000312664,
ENSP00000481929,
ENSP00000340030
RefSeq:
NP_001215.1,
NP_116764.2,
NP_116765.2
|
| Others |
UniRef100:
UniRef100_P42575,
UniRef100_D3DXD8,
UniRef100_A0A087WYM1
UniRef90:
UniRef90_P42575,
UniRef90_A0A3Q2H985,
UniRef90_A0A2K5REM9
UniRef50:
UniRef50_P55215-2,
UniRef50_A0A2I3N9C9,
UniRef50_P42575
UniGene:
Hs.368982
CCDS:
CCDS5879.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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