| Type | Description |
|---|---|
| Definition | deoxyhypusine hydroxylase |
| Date | Results | Publications |
|---|---|---|
| 2016-02-06 11:28:00 | Data describes 3-D structure of hDOHH in two states, hDOHHperoxo (POX) and a complex of the diiron core with glycerol (GLC) providing an explanation for the extreme longevity of POX and illustrate its substrate specificity for deoxyhypusine-eIF-5A. | 25865244 |
| 2014-08-23 10:37:00 | Here, we show that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor eukaryotic initiation factor 5A. | 24843120 |
| 2013-02-02 11:25:00 | eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample | 22927971 |
| 2013-01-05 10:54:00 | a novel role for miR-331-3p and miR-642-5p in the control of prostate cancer cell growth via the regulation of DOHH expression and eIF5A activity. | 22908221 |
| 2010-01-21 00:00:00 | Resonance Raman experiments show that its blue chromophore arises from a (mu-1,2-peroxo)diiron(III) center that forms in the reaction of the reduced enzyme with O2, so the peroxo form of hDOHH is unusually stable. | 19706422 |
| Type | IDs |
|---|---|
| Synonymous | HLRC1, hDOHH |
| Gene |
UniProtKB-ID:
DOHH_HUMAN
UniprotKB:
Q9BU89
UniParc:
UPI0000071C59
EMBL:
BC002817,
BC009863,
AC005551,
AC093052
Ensembl:
ENSG00000129932
KO:
hsa:83475
|
| Nucleutide sequences |
EMBL-CDS:
AAH09863.1,
AAH02817.1,
AAC33193.1
Ensembl_TRS:
ENST00000427575,
ENST00000672935
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000398882,
ENSP00000500806
RefSeq:
NP_112594.1,
XP_011526643.1,
NP_001138637.1
|
| Others |
UniRef100:
UniRef100_Q9BU89
UniRef90:
UniRef90_Q9BU89
UniRef50:
UniRef50_Q9BU89
UniGene:
Hs.515064,
Hs.609012
CCDS:
CCDS12108.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31091453 |
Cell Rep Adnan Shami Shah , Alex G Batrouni , Dongsung Kim , Amith Punyala , Wendy Cao , Chun Han , Michael L Goldberg , Marcus B Smolka , Jeremy M Baskin |
2019-05-14 | - |
| 30463901 |
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. Genes Dev. Lei Yu , Natee Jearawiriyapaisarn , Mary P Lee , Tomonori Hosoya , Qingqing Wu , Greggory Myers , Kim-Chew Lim , Ryo Kurita , Yukio Nakamura , Anne B Vojtek , Jean-François Rual , James Douglas Engel |
2018-12-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 26344197 |
Panorama of ancient metazoan macromolecular complexes. Nature Cuihong Wan , Blake Borgeson , Sadhna Phanse , Fan Tu , Kevin Drew , Greg Clark , Xuejian Xiong , Olga Kagan , Julian Kwan , Alexandr Bezginov , Kyle Chessman , Swati Pal , Graham Cromar , Ophelia Papoulas , Zuyao Ni , Daniel R Boutz , Snejana Stoilova , Pierre C Havugimana , Xinghua Guo , Ramy H Malty , Mihail Sarov , Jack Greenblatt , Mohan Babu , W Brent Derry , Elisabeth R Tillier , John B Wallingford , John Parkinson , Edward M Marcotte , Andrew Emili |
2015-09-17 |
AKT3,
MED6,
ABI1,
GNPDA1,
SRA1,
TDRD15,
HMGN1P30,
PDCD6IP,
PDCD6,
MED16,
ADA,
CHAF1A,
TOM1,
RANBP9,
SMC4,
ARPC4-TTLL3,
RBM14-RBM4,
RNF103-CHMP3,
CHURC1-FNTB,
AP1M2,
ISY1-RAB43,
UBA2,
SAE1,
FARSB,
DNM1L,
ABCF2,
COX17,
SCAMP2,
SCAMP3,
DPP3,
SNUPN,
HUWE1,
TSSC4,
ATP9A,
PQBP1,
COL4A3BP,
PTGES3L-AARSD1,
ARPC5,
ARPC4,
ARPC3,
ARPC1B,
ACTR3,
ACTR2,
NUBP2,
PPIF,
LOC101060521,
ARPC2,
RAD50,
ACTR1B,
ACTR1A,
ADAM8,
LRPPRC,
PDIA6,
TRAP1,
BCAP31,
NAMPT,
RBM12,
G3BP1,
ABI2,
CEBPZ,
TRIM28,
AASS,
ATP6AP2,
WASF2,
SLC25A13,
CDK2,
RBM7,
ALYREF,
TXNDC9,
LOC101929876,
PSME3,
MPHOSPH10,
MPHOSPH6,
CDK5,
NUTF2,
EIF1,
DDX39A,
PSMD14,
CDK7,
PLIN3,
HNRNPR,
MRPS31,
CDK8,
RABEPK,
RIDA,
SRRM1,
CDK9,
STAM2,
SF3B4,
ZMPSTE24,
AKAP8,
STUB1,
STAG1,
UBE4B,
PRSS16,
SIGMAR1,
BET1,
CWC27,
SAP18
|
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 25865244 |
Structure Zhenggang Han , Naoki Sakai , Lars H Böttger , Sebastián Klinke , Joachim Hauber , Alfred X Trautwein , Rolf Hilgenfeld |
2015-05-05 | - |
| 24843120 |
Proc. Natl. Acad. Sci. U.S.A. Avery G Frey , Anjali Nandal , Jong Hwan Park , Pamela M Smith , Toshiki Yabe , Moon-Suhn Ryu , Manik C Ghosh , Jaekwon Lee , Tracey A Rouault , Myung Hee Park , Caroline C Philpott |
2014-06-03 |
PCBP1,
PCBP2,
DOHH
|
| 23824909 |
Mol Cell Proteomics Ying Chen , Li-Na Yang , Li Cheng , Shun Tu , Shu-Juan Guo , Huang-Ying Le , Qian Xiong , Ran Mo , Chong-Yang Li , Jun-Seop Jeong , Lizhi Jiang , Seth Blackshaw , Li-Jun Bi , Heng Zhu , Sheng-Ce Tao , Feng Ge |
2013-10-01 | - |
| 22908221 |
J Biol Chem Michael R Epis , Keith M Giles , Felicity C Kalinowski , Andrew Barker , Ronald J Cohen , Peter J Leedman |
2012-10-12 | - |
| 22190034 |
Global landscape of HIV-human protein complexes. Nature Stefanie Jäger , Peter Cimermancic , Natali Gulbahce , Jeffrey R Johnson , Kathryn E McGovern , Starlynn C Clarke , Michael Shales , Gaelle Mercenne , Lars Pache , Kathy Li , Hilda Hernandez , Gwendolyn M Jang , Shoshannah L Roth , Eyal Akiva , John Marlett , Melanie Stephens , Iván D'Orso , Jason Fernandes , Marie Fahey , Cathal Mahon , Anthony J O'Donoghue , Aleksandar Todorovic , John H Morris , David A Maltby , Tom Alber , Gerard Cagney , Frederic D Bushman , John A Young , Sumit K Chanda , Wesley I Sundquist , Tanja Kortemme , Ryan D Hernandez , Charles S Craik , Alma Burlingame , Andrej Sali , Alan D Frankel , Nevan J Krogan |
2012-01-19 |
gag,
gag-pol,
vif,
vpr,
tat,
rev,
vpu,
env,
nef,
ACOT8,
CHAF1A,
SCAMP3,
HUWE1,
PREB,
LRPPRC,
PDIA6,
BCAP31,
AKAP9,
G3BP1,
PSME3,
FLOT1,
CDK9,
STUB1,
CDKN2A,
RTN3,
NPM3,
TOMM40,
CLGN,
ATP5H,
EIF3M,
CARM1,
HYOU1,
SSSCA1,
PRDX4,
ARFGEF2,
ARFGEF1,
SPAG5,
IVNS1ABP,
NFAT5,
NUDC,
PTGES3,
AHCYL1,
MTHFD2,
SDCCAG8,
HSPH1,
PGRMC1,
COPS8,
SF3A3,
PDIA5,
OS9,
LMAN2,
CKAP4,
TMED10,
COPS6,
COPS5,
SLC27A4,
RER1,
PSIP1,
STRAP,
CHI3L2,
DDX20,
CHP1,
PHB2,
OSBPL6,
CKMT1B,
CHCHD1,
LSM12,
MITD1,
COMT,
COX4I1,
COX6B1,
VTI1A,
PARP4,
DPY19L3,
SLC30A7,
CTSB,
CTSD,
DARS,
ZNF579,
TOR1AIP2,
DDB1,
DDX6,
TIMM8A,
DHCR24,
DIAPH1,
DYNC1H1,
DYNC1I2,
DOK1,
DSC3,
DSP,
TOR1A,
AHCY,
FLCN,
TMEM192,
EPRS,
ACSL3,
PTK2B,
TYSND1,
FBN2
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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{{author.size}} |
目前还没有研究热点人员