| Type | Description |
|---|---|
| Definition | aph-1 homolog B, gamma-secretase subunit |
| Date | Results | Publications |
|---|---|---|
| 2017-06-24 12:23:00 | Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2)/Aph1aL, PS2/Aph1aS and PS2/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases. | 27608597 |
| 2014-05-10 14:30:00 | gamma-Secretase inhibition during repeated peripheral inflammation blocks central amyloid-beta accumulation and prevents cognitive dysfunction. | 23665252 |
| 2010-01-21 00:00:00 | These results collectively indicate that the three forms of APH-1 can replace each other in presenilin (PS) complexes and that the transmembrane GxxxG region is essential for the stability of the APH-1 protein as well as the assembly of PS complexes. | 16757808 |
| 2010-01-21 00:00:00 | dimeric (NCSTN/APH-1) and trimeric (NCSTN/APH-1/PS1) intermediates of gamma-secretase complex assembly are retained within the ER and incorporation of the fourth binding partner (PEN-2) also occurs on immature NCSTN (APH-1) | 15591316 |
| 2010-01-21 00:00:00 | knock down of APH-1a, but not APH-1b, resulted in impaired maturation of nicastrin and reduced expression of presenilin 1, presenilin 2, and PEN-2 proteins | 15629423 |
| Type | IDs |
|---|---|
| Synonymous | APH-1B, PRO1328, PSFL, TAAV688 |
| Gene |
UniProtKB-ID:
APH1B_HUMAN
UniprotKB:
Q8WW43
UniParc:
UPI000004222D,
UPI00005056C0
EMBL:
AY358698,
AC016207,
AL136671,
CH471082,
AB189172,
AK291204,
AF508794,
BC020905
Ensembl:
ENSG00000138613
KO:
hsa:83464
|
| Nucleutide sequences |
EMBL-CDS:
AAH20905.1,
BAF83893.1,
BAD95573.1,
AAQ89061.1,
CAB66606.1,
EAW77645.1,
AAN63817.1
Gene_ORFName:
UNQ688/PRO1328
Ensembl_TRS:
ENST00000261879,
ENST00000380343
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000369700,
ENSP00000261879
RefSeq:
XP_024305854.1,
XP_024305853.1,
NP_001139118.1,
NP_112591.2,
XP_011520407.1
|
| Others |
UniRef100:
UniRef100_Q8WW43
UniRef90:
UniRef90_Q8WW43
UniRef50:
UniRef50_Q8WW43
UniGene:
Hs.511703
CCDS:
CCDS45276.1,
CCDS10184.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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