| Type | Description |
|---|---|
| Definition | ER membrane protein complex subunit 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:26:00 | Adenovirus-mediated ectopic overexpression of EMC6 (Ad5-EMC6) decreases the activity of ERK1/2, down-regulates the levels of BCL-2 and increases the ratio of BAX/BCL-2. Ad5-EMC6 mediates anti-tumor activity through the mitochondrial apoptosis pathway. Ad5-EMC6 enhances the sensitivity of gastric cancer cells to the etoposide. | 30982575 |
| 2018-07-14 10:38:00 | The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 and Rab5a. | 28742203 |
| 2018-05-12 10:18:00 | This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored. | 28648145 |
| 2013-07-13 11:32:00 | Endoplasmic membrane protein complex subunit 6 (EMC6) interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1. | 23182941 |
| Type | IDs |
|---|---|
| Synonymous | RAB5IFL, TMEM93 |
| Gene |
UniProtKB-ID:
EMC6_HUMAN
UniprotKB:
Q9BV81
UniParc:
UPI00000212D2
EMBL:
BC001409
Ensembl:
ENSG00000127774
KO:
hsa:83460
|
| Nucleutide sequences |
EMBL-CDS:
AAH01409.1
Ensembl_TRS:
ENST00000397133,
ENST00000248378
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000380322,
ENSP00000248378
RefSeq:
NP_112588.1,
NP_001014764.1
|
| Others |
UniRef100:
UniRef100_Q9BV81
UniRef90:
UniRef90_Q9BV81
UniRef50:
UniRef50_Q9BV81
UniGene:
Hs.30011
CCDS:
CCDS11033.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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