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83460 EMC6

83460

EMC6

ER membrane protein complex subunit 6

protein-coding

Homo sapiens

基因描述

Type Description
Definition ER membrane protein complex subunit 6

研究结论

Date Results Publications
2020-06-27 11:26:00 Adenovirus-mediated ectopic overexpression of EMC6 (Ad5-EMC6) decreases the activity of ERK1/2, down-regulates the levels of BCL-2 and increases the ratio of BAX/BCL-2. Ad5-EMC6 mediates anti-tumor activity through the mitochondrial apoptosis pathway. Ad5-EMC6 enhances the sensitivity of gastric cancer cells to the etoposide. 30982575
2018-07-14 10:38:00 The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 and Rab5a. 28742203
2018-05-12 10:18:00 This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored. 28648145
2013-07-13 11:32:00 Endoplasmic membrane protein complex subunit 6 (EMC6) interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1. 23182941

名称对应

Type IDs
Synonymous RAB5IFL, TMEM93
Gene
UniProtKB-ID: EMC6_HUMAN
UniprotKB: Q9BV81
UniParc: UPI00000212D2
EMBL: BC001409
Ensembl: ENSG00000127774
KO: hsa:83460
Nucleutide sequences
EMBL-CDS: AAH01409.1
Ensembl_TRS: ENST00000397133, ENST00000248378
Protein sequencees
Ensembl_PRO: ENSP00000380322, ENSP00000248378
RefSeq: NP_112588.1, NP_001014764.1
Others
UniRef100: UniRef100_Q9BV81
UniRef90: UniRef90_Q9BV81
UniRef50: UniRef50_Q9BV81
UniGene: Hs.30011
CCDS: CCDS11033.1

全选

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研究热度

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