| Type | Description |
|---|---|
| Definition | caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-09-26 13:07:00 | Genomic sequencing highlights the diverse molecular causes of Perrault syndrome: a peroxisomal disorder (PEX6), metabolic disorders (CLPP, GGPS1), and mtDNA maintenance/translation disorders (LARS2, TFAM). | 32399598 |
| 2020-06-27 10:54:00 | ClpP is selectively decreased in alphaSyn-expressing cell culture and neurons derived from iPS cells of PD patient carrying alphaSyn A53T mutant, and in dopaminergic neurons of alphaSyn A53T mice and PD patient postmortem brains. ClpP loss damages mitochondria. Overexpression causes oxidative stress and suppresses alphaSyn phosphorylation. alphaSyn WT and A53T mutant interact with ClpP and suppress its peptidase activity. | 30877431 |
| 2020-04-11 12:55:00 | Results found that CLPP influenced mitochondrial respiration only under conditions of oxidative stress. | 30878663 |
| 2019-05-04 12:02:00 | Mitochondrial overexpression of human ClpP protects HeLa cells from killing by cisplatin. Overexpression of human ClpP desensitizes cells to cisplatin. | 26675528 |
| 2017-12-02 11:22:00 | Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. | 28449241 |
| Type | IDs |
|---|---|
| Synonymous | DFNB81, PRLTS3 |
| Gene |
UniProtKB-ID:
CLPP_HUMAN
UniprotKB:
Q16740
UniParc:
UPI0000000C4D
EMBL:
BC002956,
AK311973,
Z50853
Ensembl:
ENSG00000125656
KO:
hsa:8192
|
| Nucleutide sequences |
EMBL-CDS:
BAG34912.1,
CAA90705.1,
AAH02956.1
Ensembl_TRS:
ENST00000245816
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000245816
RefSeq:
NP_006003.1
|
| Others |
UniRef100:
UniRef100_Q16740
UniRef90:
UniRef90_Q16740
UniRef50:
UniRef50_Q16740
UniGene:
Hs.515092
CCDS:
CCDS12162.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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