Type | Description |
---|---|
Definition | splicing factor 3b, subunit 1 |
Date | Results | Publications |
---|---|---|
2019-12-07 11:40:00 | Conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell development, and induces a state of cellular senescence. Combination with Atm deletion leads to the overcoming of cellular senescence and the development of chronic lymphocytic leukemia. | 30712845 |
2017-09-02 11:21:00 | Our findings demonstrate that, despite significant differences in affected transcripts, there is overlap in the phenotypes associated with SF3B1-K700E between human and mouse. | 27604819 |
2017-08-26 11:25:00 | Sf3b1(K700E) mice develop macrocytic anemia due to a terminal erythroid maturation defect, erythroid dysplasia, and long-term hematopoietic stem cell (LT-HSC) expansion. | 27622333 |
2015-08-01 10:51:00 | myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha) activation of SF3B1 and SF3B1-mediated splice switching of KHK-A to KHK-C | 26083752 |
2015-05-23 12:43:00 | Sf3b1 isrequired for the blastocyst formation. | 23211737 |
Type | IDs |
---|---|
Synonymous | 155kDa, 2810001M05Rik, AA409119, Prp10, SAP155, SF3b155, TA-8, Targ4 |
Gene |
UniProtKB-ID:
Q3US00_MOUSE,
Q8C839_MOUSE,
Q8C2Y9_MOUSE,
G5E866_MOUSE
UniprotKB:
Q3US00,
Q8C839,
Q8C2Y9,
G5E866
UniParc:
UPI000013D493,
UPI00000E9FC3,
UPI00000E992A,
UPI00005AC01C
EMBL:
AK087700,
AC108391,
AK048521,
AK140982,
AC166111
Ensembl:
ENSMUSG00000025982
KO:
mmu:81898
|
Nucleutide sequences |
EMBL-CDS:
BAE24537.1,
BAC33358.1,
BAC39971.1
Ensembl_TRS:
ENSMUST00000027127
|
Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027127
RefSeq:
XP_036010350.1,
NP_112456.2,
XP_036010348.1
|
Others |
UniRef100:
UniRef100_Q8C839,
UniRef100_O75533,
UniRef100_A0A286XGH7
UniRef90:
UniRef90_Q99NB9,
UniRef90_O75533,
UniRef90_Q8C839
UniRef50:
UniRef50_A0A673SYZ3,
UniRef50_Q99NB9,
UniRef50_O75533
UniGene:
Mm.279736
|
{{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
---|---|---|---|---|---|---|---|---|
Refseq |
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