| Type | Description |
|---|---|
| Definition | mediator complex subunit 25 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-07 10:04:00 | recurrent MED25 frameshift mutation in the C7 repeat (c.602delC) that would result in a frameshift mutation (p. Pro201ArgfsX13) were detected in the colorectal cancers with microsatellite instability-high, but not in those with microsatellite-stability | 27406034 |
| 2017-10-14 12:01:00 | FOS strongly binds to the same MED25 site as ETV4 activation domain and JUN interacts with the other two MED25 sites. | 28728983 |
| 2017-03-04 12:44:00 | Med25, a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha that interacts with ERalpha through its C-terminal LXXLL motif after BPA exposure, and is functionally involved in BPA-induced transcriptional regulation of CYP2C9 expression and enzyme activity. | 27273787 |
| 2016-02-27 10:52:00 | the critical region of chromosome 19 a homozygous variant (c.418C>T, p.Arg140Trp) in Mediator complex subunit 25 predicted as deleterious. | 25527630 |
| 2015-11-28 11:07:00 | A model is proposed in which the N-terminal transactivation domain of ERM binds the MED25 VP16 H1 binding pocket in a helical conformation. | 26130716 |
| Type | IDs |
|---|---|
| Synonymous | ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758 |
| Gene |
UniProtKB-ID:
MED25_HUMAN
UniprotKB:
Q71SY5
UniParc:
UPI00002029A3,
UPI000191F59E,
UPI00015C73F0,
UPI000041F28F
EMBL:
AC006942,
AF261072,
AL136746,
AF283769,
AC018766,
AJ617479,
AY533507,
CH471177,
AK289460,
BC065297,
BC024312,
EU392500
Ensembl:
ENSG00000104973
KO:
hsa:81857
|
| Nucleutide sequences |
EMBL-CDS:
AAG15589.1,
AAS45401.1,
AAH65297.1,
BAF82149.1,
AAD15565.1,
EAW52546.1,
CAB66680.1,
AAH24312.2,
ACB88862.1,
AAM20739.1,
CAE84581.1
Gene_ORFName:
TCBAP0758
Ensembl_TRS:
ENST00000538643,
ENST00000312865
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000437496,
ENSP00000326767
RefSeq:
NP_112235.2,
NP_001365284.1
|
| Others |
UniRef100:
UniRef100_Q71SY5
UniRef90:
UniRef90_Q71SY5
UniRef50:
UniRef50_Q71SY5
UniGene:
Hs.656639,
Hs.745568
CCDS:
CCDS33075.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员