Pggt1b - protein geranylgeranyltransferase type 1 subunit beta-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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81746 Pggt1b

基因描述

Type	Description
Definition	protein geranylgeranyltransferase type 1 subunit beta

研究结论

Date	Results	Publications
2010-09-06 12:21:00	Results indicate that geranylgeranyltransferase I (GGT) plays an important role in Purkinje cell development, and suggest a novel role of GGT in neuronal morphogenesis in vivo.	20540740
2010-01-21 00:00:00	lysine beta311 of GGTase I partially replaces the catalytic function of Mg(II) observed in FTas	15131129

名称对应

Type	IDs
Gene	UniProtKB-ID: PGTB1_RAT UniprotKB: P53610 UniParc: UPI0000049049 EMBL: L24116 Ensembl: ENSRNOG00000003541 KO: rno:81746
Nucleutide sequences	EMBL-CDS: AAA17756.1 Ensembl_TRS: ENSRNOT00000004723
Protein sequencees	Ensembl_PRO: ENSRNOP00000004723 RefSeq: NP_112344.1, XP_008770399.1
Others	UniRef100: UniRef100_P53610 UniRef90: UniRef90_P53610 UniRef50: UniRef50_P53610 UniGene: Rn.10031

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20540740	Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells. Mol Brain Kong-Yan Wu , Xiu-Ping Zhou , Zhen-Ge Luo	2010-01-01	Pggt1b
18957540	TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis. Proc. Natl. Acad. Sci. U.S.A. Xiu-Ping Zhou , Kong-Yan Wu , Bin Liang , Xiu-Qing Fu , Zhen-Ge Luo	2008-11-04	Ntrk2, Fnta, Fntb, Pggt1b
16893176	Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry Kimberly L Terry , Patrick J Casey , Lorena S Beese	2006-08-15	FNTA, FNTB, PGGT1B
15451670	Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J. Mol. Biol. T Scott Reid , Kimberly L Terry , Patrick J Casey , Lorena S Beese	2004-10-15	Fnta, Fntb, Pggt1b, RRAS2, FNTA, FNTB, HRAS, KRAS, RHOB, PGGT1B, GNG2, RAP2A, CDC42
15248757	Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Biochemistry T Scott Reid , Stephen B Long , Lorena S Beese	2004-07-20	-
15131129	Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. J Biol Chem Heather L Hartman , Katherine E Bowers , Carol A Fierke	2004-07-16	-
14609943	Structure of mammalian protein geranylgeranyltransferase type-I. EMBO J. Jeffrey S Taylor , T Scott Reid , Kimberly L Terry , Patrick J Casey , Lorena S Beese	2003-11-17	Fnta, Pggt1b
10544242	Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells. FEBS Lett. J L Mazet , M Padieu , H Osman , G Maume , P Mailliet , N Dereu , A D Hamilton , F Lavelle , S M Sebti , B F Maume	1999-10-29	-
9705207	Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase. Arch. Biochem. Biophys. R Roskoski , P Ritchie	1998-08-15	Fnta, Fntb, Pggt1b

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