| Type | Description |
|---|---|
| Definition | phosphodiesterase 2A |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 12:05:00 | PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria. | 31100470 |
| 2018-02-10 10:49:00 | Using pharmacological and genetic approaches combined with real-time FRET imaging and high resolution microscopy, we demonstrate that in rat cardiac myocytes and other cell types mitochondrial PDE2A2 regulates local cAMP levels and phosphorylation of Drp1. | 28463107 |
| 2016-04-23 11:34:00 | results indicate interventricular differences in PDE2 transcript and activity levels, which may distinctly regulate beta2 adrenoceptor-mediated contractility and cAMP concentrations in the right and left ventricles | 25432985 |
| 2016-01-02 10:04:00 | Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by PDE2A. | 26243800 |
| 2015-08-29 10:47:00 | Pde2 overexpression decreased BNP stimulation of cGMP and BNP responses to the Ca current, intracellular Ca transient, and neurotransmitter release. Pde2 was higher in stellate neurons from prohypertensive rats vs normotensives. | 25916722 |
| Type | IDs |
|---|---|
| Synonymous | CGS-PDE, Pde2, Pde2a2 |
| Gene |
UniProtKB-ID:
PDE2A_RAT,
A0A0G2K876_RAT,
F8WFW5_RAT
UniprotKB:
Q01062,
A0A0G2K876,
F8WFW5
UniParc:
UPI0000500839,
UPI0000127BEC,
UPI0002742D10
EMBL:
AC122631,
M94540,
U21101,
AC128828
Ensembl:
ENSRNOG00000019560
KO:
rno:81743
|
| Nucleutide sequences |
EMBL-CDS:
AAA63683.1,
AAA40922.1
Ensembl_TRS:
ENSRNOT00000090959,
ENSRNOT00000026586
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000074500,
ENSRNOP00000026586
RefSeq:
NP_112341.1,
NP_001137319.1,
NP_001257533.1
|
| Others |
UniRef100:
UniRef100_A0A0G2K876,
UniRef100_F8WFW5,
UniRef100_Q01062
UniRef90:
UniRef90_Q01062
UniRef50:
UniRef50_Q922S4
UniGene:
Rn.10044
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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