| Type | Description |
|---|---|
| Definition | lanosterol synthase |
| Date | Results | Publications |
|---|---|---|
| 2010-01-21 00:00:00 | These observations suggest an involvement of PCSK9 in hepatic LDL receptor protein degradation and perhaps, in increasing the rate of LDL receptor cycling resulting in lower serum cholesterol levels in response to cholesterol biosynthesis inhibitors. | 18054775 |
| 2010-01-21 00:00:00 | Data suggest that cholesterol insufficiency due to mutation in lanosterol synthase may underlie the deficient proliferation of lens epithelial cells, which may eventually lead to cataractogenesis in Shumiya cataract rats. | 16440058 |
| 2010-01-21 00:00:00 | The hypomorphic Lss(S) and Fdft1(S) alleles are not specific to the SCR strain, but are widely prevalent in several other laboratory rat strains. | 17460354 |
| 2010-01-21 00:00:00 | Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. | 19119143 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
LSS_RAT
UniprotKB:
P48450
UniParc:
UPI00004EAC9F
EMBL:
D45252,
U31352
KO:
rno:81681
|
| Nucleutide sequences |
EMBL-CDS:
AAA91023.1,
BAA08208.1
|
| Protein sequencees |
RefSeq:
NP_112311.2
|
| Others |
UniRef100:
UniRef100_P48450
UniRef90:
UniRef90_P48450
UniRef50:
UniRef50_P48450
UniGene:
Rn.10211
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 30401459 |
Am J Hum Genet Maria-Teresa Romano , Aylar Tafazzoli , Maximilian Mattern , Sugirthan Sivalingam , Sabrina Wolf , Alexander Rupp , Holger Thiele , Janine Altmüller , Peter Nürnberg , Jürgen Ellwanger , Reto Gambon , Alessandra Baumer , Nicolai Kohlschmidt , Dieter Metze , Stefan Holdenrieder , Ralf Paus , Dieter Lütjohann , Jorge Frank , Matthias Geyer , Marta Bertolini , Pavlos Kokordelis , Regina C Betz |
2018-11-01 | - |
| 26200341 |
Lanosterol reverses protein aggregation in cataracts. Nature Ling Zhao , Xiang-Jun Chen , Jie Zhu , Yi-Bo Xi , Xu Yang , Li-Dan Hu , Hong Ouyang , Sherrina H Patel , Xin Jin , Danni Lin , Frances Wu , Ken Flagg , Huimin Cai , Gen Li , Guiqun Cao , Ying Lin , Daniel Chen , Cindy Wen , Christopher Chung , Yandong Wang , Austin Qiu , Emily Yeh , Wenqiu Wang , Xun Hu , Seanna Grob , Ruben Abagyan , Zhiguang Su , Harry Christianto Tjondro , Xi-Juan Zhao , Hongrong Luo , Rui Hou , J Jefferson , P Perry , Weiwei Gao , Igor Kozak , David Granet , Yingrui Li , Xiaodong Sun , Jun Wang , Liangfang Zhang , Yizhi Liu , Yong-Bin Yan , Kang Zhang |
2015-07-30 | - |
| 25168180 |
Toxicology Alice Marmugi , Frederic Lasserre , Diane Beuzelin , Simon Ducheix , Laurence Huc , Arnaud Polizzi , Maud Chetivaux , Thierry Pineau , Pascal Martin , Hervé Guillou , Laila Mselli-Lakhal |
2014-11-05 | - |
| 22871113 |
Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. J. Proteome Res. Chan Hyun Na , Drew R Jones , Yanling Yang , Xusheng Wang , Yanji Xu , Junmin Peng |
2012-09-07 |
Rab1b,
Tmem59,
Msh6,
LOC100360426,
Sncb,
Csnk1a1,
Magi2,
Cxcl2,
Dnm1l,
Gng3,
Hcn2,
Clasp2,
Ubqln1,
Gne,
Stx1a,
Txn1,
Sec14l2,
Gripap1,
Mprip,
Slc6a9,
Ralb,
Ap2m1,
Nrxn2,
Slc17a7,
Vcp,
Cap2,
Dlgap2,
Lmnb1,
Trim28,
Epb41l3,
Ube2n,
Gp1bb,
Nup155,
Bin1,
Rpl6,
H3f3b,
Nlgn2,
Prdx1,
Psmc4,
Psmc1,
Epn1,
Ppp2r1a,
Hnrnpk,
Lrrc7,
Txnip,
Uba3,
Sv2b,
Tpm3,
Sv2a,
Atp6v1b2,
Rps20,
Slc8a2,
Rps3,
Faf1,
Ap2b1,
Dnm1,
Cacng8,
Cdk5,
Txnl1,
Ggt7,
Prkcd,
Palm,
Atp2c1,
Dynlrb1,
Kcnh7,
Xpnpep1,
Atxn10,
Kcnq2,
Cry2,
Rab3c,
Ndrg2,
Camk2g,
Pabpc1,
Eef1a1,
Slc12a5,
Acsbg1,
Tmem176b,
Nme1,
Tecr,
Syngap1,
Hip1,
Gpm6b,
Ehd4,
Rasgrf1,
Plpp3,
Stip1,
Caly,
Aldoa,
Aldoc,
Atp1a1,
Atp1a2,
Atp1a3,
Atp2b2,
Cacna1c,
Calm1,
Camk2d,
Ckb,
Eno1,
Gapdh
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 21498505 |
J Biol Chem Christine Moessinger , Lars Kuerschner , Johanna Spandl , Andrej Shevchenko , Christoph Thiele |
2011-06-17 | - |
| 19946888 |
Defining the membrane proteome of NK cells. J Mass Spectrom Dhimankrishna Ghosh , Dustin Lippert , Oleg Krokhin , John P Cortens , John A Wilkins |
2010-01-01 |
MED6,
PDCD6IP,
MED16,
PIGK,
DNAJB6,
FARSB,
DNM1L,
ABCF2,
HUWE1,
ARPC3,
ACTR3,
ACTR2,
RAD50,
PREB,
ACTR1B,
LRPPRC,
TRAP1,
BCAP31,
PLXNC1,
LPCAT3,
TNK2,
PSME3,
MPHOSPH9,
FLOT1,
DDX39A,
AK6,
ADAM10,
PLIN3,
CALCOCO2,
CDK9,
ABCC4,
ZMPSTE24,
AKAP8,
BET1,
MARCH6,
KATNB1,
ADAR,
EMC8,
BTN3A3,
ATP8A1,
NDC80,
CDIPT,
PGRMC2,
TUBGCP3,
ECI2,
COG5,
SLC25A17,
LRRC41,
SYNCRIP,
MYBBP1A,
DDX17,
CHERP,
HYOU1,
IPO7,
NOP56,
ARL6IP5,
HTATIP2,
AGPAT1,
ARFGEF2,
RABAC1,
SLU7,
PRPF8,
PAICS,
CENPE,
PMVK,
KHDRBS1,
CELF1,
GNA13,
CFL1,
MGEA5,
YME1L1,
STAG2,
CTSC,
GIPC1,
HBS1L,
TUBGCP2,
PGRMC1,
MAN1A2,
PNPLA6,
MAGED2,
ADCY3,
EHD1,
TOMM34,
ERP29,
YWHAQ,
ASCC3,
GCN1,
IMMT,
ILVBL,
SLC27A4,
SLC27A3,
KIF2C,
GLIPR1,
CPSF6,
DDX52,
WWP2,
CNTRL,
CHD4,
KRR1
|
| 19119143 |
J Biol Chem Huaixin Dang , Yan Liu , Wei Pang , Chenghong Li , Nanping Wang , John Y-J Shyy , Yi Zhu |
2009-03-06 | - |
| 18054775 |
Inhibition of squalene synthase upregulates PCSK9 expression in rat liver. Arch. Biochem. Biophys. Mohini Bedi , Melissa Niesen , Dayami Lopez |
2008-02-15 |
Pcsk9,
Lss
|
| 17460354 |
Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats. Exp. Anim. Masayuki Mori , Jinko Sawashita , Keiichi Higuchi |
2007-04-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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目前还没有研究热点人员