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81657 Gabbr1

81657

Gabbr1

gamma-aminobutyric acid type B receptor subunit 1

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition gamma-aminobutyric acid type B receptor subunit 1

研究结论

Date Results Publications
2021-03-27 14:44:00 Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats. 32717394
2017-11-25 15:47:00 Transient activation of mGluRs decreased the GIRK current evoked by GABAB and D2 receptors, although less efficaciously for D2. 28009293
2017-08-26 10:58:00 We demonstrate that GABABR activation can regulate KCC2 at the cell surface in a manner that alters intracellular chloride and the reversal potential for the GABAAR. Our data therefore support an additional mechanism by which GABABRs are able to modulate fast synaptic inhibition. 28450542
2017-05-20 15:04:00 sustained activation of glutamate receptors, a condition occurring in brain ischemia that down-regulates GABAB receptors, considerably increased the expression of MIB2 and Lys-63-linked ubiquitination of GABAB receptors. Interfering with Lys-63-linked ubiquitination by overexpressing ubiquitin mutants or GABAB1 mutants deficient in Lys-63-linked ubiquitination prevented glutamate-induced down-regulation of the receptors. 27573246
2016-12-17 10:44:00 Both synaptic processes were critically dependent on activation of GABAB receptors and, together, appeared to temporally segregate the cortical representation. These data suggest that adaptation to repetitive sensory input dramatically alters the spatiotemporal properties of the neocortical response in a manner that may both refine and minimize cortical output simultaneously. 27118845

名称对应

Type IDs
Gene
UniProtKB-ID: GABR1_RAT, Q6MFX8_RAT
UniprotKB: Q9Z0U4, Q6MFX8
UniParc: UPI000002AA44, UPI000002AA41, UPI000002AA42, UPI000002AA43, UPI000012B267
EMBL: AB016161, Y10369, AF110797, BX883052, AF110796, AB016160, Y10370
Ensembl: ENSRNOG00000000774
KO: rno:81657
Nucleutide sequences
EMBL-CDS: AAD19658.1, BAA34708.1, AAD19659.1, AAD19657.1, BAA34709.1, CAA71398.1, CAA71399.1, AAD19656.1, CAE84069.1
Ensembl_TRS: ENSRNOT00000082545, ENSRNOT00000085050, ENSRNOT00000084582, ENSRNOT00000051634, ENSRNOT00000088396
Protein sequencees
Ensembl_PRO: ENSRNOP00000072226, ENSRNOP00000075630, ENSRNOP00000047498, ENSRNOP00000075610, ENSRNOP00000075181
RefSeq: NP_112290.2, XP_006255941.1
Others
UniRef100: UniRef100_Q9Z0U4, UniRef100_Q6MFX8
UniRef90: UniRef90_Q9UBS5-3, UniRef90_Q9Z0U4
UniRef50: UniRef50_Q9UBS5, UniRef50_Q9Z0U4
UniGene: Rn.30059

全选

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