| Type | Description |
|---|---|
| Definition | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Date | Results | Publications |
|---|---|---|
| 2015-07-06 13:24:00 | Data identified ATIC as a physical partner of internalized insulin receptor (IR) in purified Golgi-endosomes (G/E) fractions of rat's liver. They show that ATIC later accumulates in G/E . SiRNA-mediated partial knockdown of ATIC decreased tyrosine phosphorylation of IR and regulated IR endocytosis in HEK293 cells. Treatment with ATIC substrate AICAR, which is an allosteric activator of AMPK, increased IR endocytosis. | 25687571 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PUR9_RAT
UniprotKB:
O35567
UniParc:
UPI000019BF08
EMBL:
D89514,
BC072496
Ensembl:
ENSRNOG00000015511
KO:
rno:81643
|
| Nucleutide sequences |
EMBL-CDS:
BAA22837.1,
AAH72496.1
Ensembl_TRS:
ENSRNOT00000021105
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000021105
RefSeq:
NP_112276.2
|
| Others |
UniRef100:
UniRef100_O35567
UniRef90:
UniRef90_P31939
UniRef50:
UniRef50_P31939
UniGene:
Rn.15114
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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