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81622 UNC93B1

81622

UNC93B1

unc-93 homolog B1, TLR signaling regulator

protein-coding

Homo sapiens

基因描述

Type Description
Definition unc-93 homolog B1, TLR signaling regulator

研究结论

Date Results Publications
2021-04-03 13:34:00 Cryo-EM structures of Toll-like receptors in complex with UNC93B1. 33432245
2020-03-28 11:54:00 UNC93B1 regulates cell-cycle arrest at the G1 phase in oral squamous cell carcinoma. Down-regulated UNC93B1 stops granulocyte macrophage colony-stimulating factor. UNC93B1 may control tumors via granulocyte macrophage colony-stimulating factor. 30935694
2019-10-12 11:05:00 Our results suggest that rare protein-altering variants in the C10orf88 and UNC93B1 genes are associated with a worse response to anti-VEGF therapy in patients with neovascular age-related macular degeneration, but these results require further validation in other cohorts. 29852030
2018-10-06 11:37:00 Expression of a constitutively active STIM1 mutant, which no longer binds UNC93B1, restores antigen degradation and cross-presentation in 3d-mutated dendritic cells. 29158474
2016-02-27 11:40:00 Endosomal localization of endogenous TLR3 was decreased by silencing of LRRC59, suggesting that LRRC59 promotes UNC93B1-mediated translocation of NA-sensing TLRs from the ER upon infection. 26466955

名称对应

Type IDs
Synonymous IIAE1, UNC93, UNC93B, Unc-93B1
Gene
UniProtKB-ID: UN93B_HUMAN
UniprotKB: Q9H1C4
UniParc: UPI000034ECF5
EMBL: AJ271326, AC004923, AJ422142, BC105104, BC101568, BC092472
Ensembl: ENSG00000110057
KO: hsa:81622
Nucleutide sequences
EMBL-CDS: AAH92472.1, AAI01569.1, CAC19791.1, CAD19522.1, AAD15416.1, AAI05105.1
Ensembl_TRS: ENST00000227471
Protein sequencees
Ensembl_PRO: ENSP00000227471
RefSeq: XP_011543593.1, NP_112192.2, XP_011543592.1
Others
UniRef100: UniRef100_Q9H1C4
UniRef90: UniRef90_Q9H1C4
UniRef50: UniRef50_Q9H1C4
UniGene: Hs.502989
CCDS: CCDS73334.1

全选

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