| Type | Description |
|---|---|
| Definition | chitinase, acidic 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-11-04 11:15:00 | The results indicate that mouse AMCase catalyzes hydrolysis as well as transglycosylation and suggest that this enzyme can play a novel role under physiological conditions in peripheral tissues, such as the lungs. | 28833103 |
| 2017-07-01 12:37:00 | we showed that M at the position 61 is highly conserved in the many mammals other than orangutan and humans. In addition, introduction of M61R and M61I to WT mouse AMCase lead to a significant reduction of its chitinolytic activity. Taken together, our present and previous data by Seibold et al. (2009) indicate that G339T (R61M) in humans is associated with asthma protection in the fashion of gain of function | 27702777 |
| 2017-06-24 10:10:00 | AMCase-deficient mice exhibit premature morbidity and mortality, concomitant with accumulation of environmentally derived chitin polymers in the airways and expression of pro-fibrotic cytokines. Over time, these mice develop spontaneous pulmonary fibrosis. | 28431248 |
| 2016-09-10 12:07:00 | Data show that acidic mammalian chitinase (AMCase) functions as a critical initiator of protective type 2 responses to intestinal nematodes, but is largely dispensable for allergic responses in the lung. | 27043413 |
| 2015-12-19 10:23:00 | AMCase expression was significantly decreased in experimental autoimmune encephalitis mice compared to PBS-controls. | 26079949 |
| Type | IDs |
|---|---|
| Synonymous | 2200003E03Rik, AMCase, Chia, YNL |
| Gene |
UniProtKB-ID:
CHIA_MOUSE
UniprotKB:
Q91XA9
UniParc:
UPI0000027402
EMBL:
BC034548,
AF154571,
AK160173,
EF094027,
BC011134,
AF290003,
DQ349202,
AK008633,
CH466608
Ensembl:
ENSMUSG00000062778
KO:
mmu:81600
|
| Nucleutide sequences |
EMBL-CDS:
ABC86699.1,
AAG60018.1,
AAH34548.1,
BAB25795.1,
BAE35672.1,
EDL07527.1,
AAH11134.1,
AAF31644.1,
ABK78778.1
Ensembl_TRS:
ENSMUST00000079132
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000078134
RefSeq:
NP_075675.2
|
| Others |
UniRef100:
UniRef100_Q91XA9
UniRef90:
UniRef90_Q91XA9
UniRef50:
UniRef50_Q91XA9
UniGene:
Mm.46418
CCDS:
CCDS38585.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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