| Type | Description |
|---|---|
| Definition | tudor domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-06 10:13:00 | Our work depicts the structural plasticity of the TDRD3 Tudor domain and paves the way for the subsequent structure-guided discovery of selective inhibitors targeting Tudor domains | 29645362 |
| 2019-01-19 10:48:00 | Study reports TDRD3 as a novel regulator of cell proliferation and invasion in breast cancer cells. Its depletion inhibits tumor formation and metastasis to the lung in vivo. Furthermore, TDRD3 regulates the expression of a number of key genes associated with promotion of breast cancer tumorigenesis and disease progression at the level of translation. | 28698590 |
| 2018-11-03 11:59:00 | Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported. | 28176834 |
| 2017-06-24 10:31:00 | Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast. | 27257063 |
| 2012-06-30 11:18:00 | The binding specificity and affinity of the Tudor domains of TDRD3, SMN and SPF30 proteins were characterized quantitatively. | 22363433 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TDRD3_HUMAN,
A0A024QZE0_HUMAN
UniprotKB:
Q9H7E2,
A0A024QZE0
UniParc:
UPI000174200C,
UPI0000136B58,
UPI00019B2224
EMBL:
CH471124,
AL354764,
BC060876,
EU643838,
AL512666,
AK024660,
BC030514,
BX537910
Ensembl:
ENSG00000083544
KO:
hsa:81550
|
| Nucleutide sequences |
EMBL-CDS:
ACC94142.1,
CAD97894.1,
AAH60876.1,
BAB14950.1,
AAH30514.1,
EAW52079.1,
EAW52082.1,
EAW52080.1
Gene_ORFName:
hCG_32165
Ensembl_TRS:
ENST00000535286,
ENST00000648252,
ENST00000621840,
ENST00000377894,
ENST00000377881,
ENST00000196169
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440190,
ENSP00000367126,
ENSP00000367113,
ENSP00000498191,
ENSP00000477993,
ENSP00000196169
RefSeq:
XP_016876266.1,
XP_024305184.1,
XP_024305185.1,
XP_024305186.1,
XP_005266617.1,
NP_110421.1,
NP_001139542.1,
XP_005266613.1,
NP_001139543.1,
XP_024305187.1
|
| Others |
UniRef100:
UniRef100_Q9H7E2
UniRef90:
UniRef90_Q9H7E2
UniRef50:
UniRef50_Q9H7E2
UniGene:
Hs.525061
CCDS:
CCDS9441.1,
CCDS53872.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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