| Type | Description |
|---|---|
| Definition | phosphodiesterase 1A |
| Date | Results | Publications |
|---|---|---|
| 2018-06-30 12:10:00 | Pde1a is the dominant PDE1 isoform present in vascular smooth muscle cells, and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling. | 28910498 |
| 2012-03-31 10:05:00 | These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis | 22012077 |
| 2011-04-16 11:08:00 | We conclude that PDE1 activation reduces cGMP bioavailability in arteries from Ang II, contributing to increased contractile responsiveness. | 21282562 |
| 2011-01-15 11:05:00 | findings provide direct evidence for the first time that PP2A B56gamma is a critical mediator for PDE1A in the regulation of beta-catenin signaling in proliferating VSMCs | 21078118 |
| 2010-04-19 11:29:00 | Expression mRNA levels of PDE1A (male > female) and PDE3B (male < female) were sex dependent in microvascular endothelial cells. | 20139324 |
| Type | IDs |
|---|---|
| Synonymous | 3'-RACEclone8phosphodiesterase1A, 3-RACEclone8phosphodiesterase1A |
| Gene |
UniProtKB-ID:
Q9EPR9_RAT
UniprotKB:
Q9EPR9
UniParc:
UPI00000E6F32
EMBL:
AF327838
KO:
rno:81529
|
| Nucleutide sequences |
EMBL-CDS:
AAG48736.1
|
| Protein sequencees |
RefSeq:
NP_110498.1
|
| Others |
UniRef100:
UniRef100_Q9EPR9
UniRef90:
UniRef90_Q61481
UniRef50:
UniRef50_P54750
UniGene:
Rn.204552
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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