| Type | Description |
|---|---|
| Definition | 8-oxoguanine DNA glycosylase |
| Date | Results | Publications |
|---|---|---|
| 2018-09-22 10:26:00 | chronic hypobaric hypoxia attenuates OGG1 expression in rat spermatozoa in a time-dependent fashion, with a greater reduction in the mitochondrial isoform OGG1-2a. | 28758699 |
| 2018-06-16 10:19:00 | The increase in the oxidative stress in compensated cardiac hypertrophy induced the OGG1-2a migration to mitochondria to repair mtDNA oxidation, as a mechanism that allows maintaining the cardiac function in the compensatory stage. | 28882450 |
| 2018-01-13 11:17:00 | Ogg1 overexpression also reduced binding of mitochondrial transcription factor A (TFAM) to both regulatory and coding regions of the mitochondrial genome without altering total abundance of TFAM in either control or hypoxic cells. These observations suggest that oxidative DNA modifications in the D-loop region during hypoxia are important for increased TFAM binding and ensuing replication of the mitochondrial genome. | 27091693 |
| 2015-12-19 11:53:00 | Oxidative DNA damage occurred in lung epithelial cells during earlystage bronchopulmonary dysplasia, as confirmed by in vitro and in vivo hyperoxia exposure experiments, and the increased expression of OGG1 was associated with this process. | 25672835 |
| 2015-04-04 12:37:00 | glucose induces apoptosis and inhibits proliferation of glial cells, which may be mediated by the phosphorylation of tuberin, down regulation of 8-oxoG-DNA glycosylase and 8-hydroxydeoxyguanosine accumulation via activation of Akt and ERK1/2MAPK pathways | 24907397 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
OGG1_RAT
UniprotKB:
O70249
UniParc:
UPI0000130C49
EMBL:
AF029690
Ensembl:
ENSRNOG00000052140
KO:
rno:81528
|
| Nucleutide sequences |
EMBL-CDS:
AAC77525.1
Ensembl_TRS:
ENSRNOT00000085766
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000070483
RefSeq:
NP_110497.1,
XP_008761420.1,
XP_017448395.1
|
| Others |
UniRef100:
UniRef100_O70249
UniRef90:
UniRef90_O70249
UniRef50:
UniRef50_O70249
UniGene:
Rn.22623
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员