| Type | Description |
|---|---|
| Definition | endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae) |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:12:00 | SIL1 is required for the development of the central nervous system which is associated with its role in Reelin signaling. | 31531014 |
| 2019-12-28 11:02:00 | SIL1 deficiency causes degenerative changes of peripheral nerves and neuromuscular junctions in fish, mice and human. The data expand the spectrum of tissues affected by SIL1-loss and suggest that impaired neuromuscular transmission might be part of Marinesco-Sjogren Syndrome pathophysiology. | 30468864 |
| 2019-03-16 10:36:00 | The protein but not the mRNA level of ORP150, a nucleotide exchange factor which can substitute for SIL1, was increased in the cerebellum of GSK2606414-treated woozy mice, suggesting that translational recovery promoted the synthesis of this alternative BiP co-factor | 29718201 |
| 2018-11-10 10:15:00 | these data reveal a disruption in endoplasmic reticulum homeostasis upon SIL1 loss, which is countered by multiple compensatory responses that are ultimately unsuccessful, leading to trans-organellar proteostasis collapse and myopathy. | 29666155 |
| 2018-04-28 10:45:00 | The carry a mutation in the Sil1 gene mice showed adult-onset ataxia with progressive neurodegeneration of the cerebellum. Homozygous wz mice might be useful as an animal model of diseases showing adult-onset ataxia because of cerebellar neurodegeneration. | 28723727 |
| Type | IDs |
|---|---|
| Synonymous | 1810057E01Rik, AI042831, wz |
| Gene |
UniProtKB-ID:
SIL1_MOUSE
UniprotKB:
Q9EPK6
UniParc:
UPI00000E8315
EMBL:
AJ297884,
AK170415,
BC016466,
BC016119
Ensembl:
ENSMUSG00000024357
KO:
mmu:81500
|
| Nucleutide sequences |
EMBL-CDS:
CAC17789.1,
BAE41781.1,
AAH16119.1,
AAH16466.1
Ensembl_TRS:
ENSMUST00000025215
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025215
RefSeq:
XP_006526428.1,
XP_036017203.1,
XP_006526430.1,
NP_109674.2,
XP_011245345.1,
NP_001347743.1,
XP_030106495.1,
XP_030106494.1
|
| Others |
UniRef100:
UniRef100_Q9EPK6
UniRef90:
UniRef90_Q9EPK6
UniRef50:
UniRef50_Q9H173
UniGene:
Mm.291482
CCDS:
CCDS29140.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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