| Type | Description |
|---|---|
| Definition | complement factor H related 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:18:00 | The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy. | 32928961 |
| 2019-08-17 10:35:00 | Higher circulating FHR-5 levels in IgA nephropathy patients were associated with a lower estimated glomerular filtration rate, hypertension, and severe Oxford-T and Oxford-C scores. High FHR-5 levels were independently and significantly associated with a risk of developing either a 30% decline in the estimated glomerular filtration rate or end-stage renal disease. | 29759419 |
| 2018-05-26 11:41:00 | Novel genetic rearrangement generated from a heterozygous deletion spanning 146 Kbp involving multiple CFHR genes leading to a CFHR1-R5 hybrid protein. This deletion was found in four family members presenting with a familial dominant glomerulopathy. | 28729035 |
| 2018-05-26 10:48:00 | Higher serum FHR-5 levels were associated with a lack of response to immunosuppression, the presence of endocapillary hypercellularity, and histology scores of IgA nephropathy severity. | 28673452 |
| 2017-05-27 11:04:00 | Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgA Nephropathy, which suggests that CFHR5 is an IgA Nephropathy susceptibility gene | 26825529 |
| Type | IDs |
|---|---|
| Synonymous | CFHL5, CFHR5D, FHR-5, FHR5 |
| Gene |
UniProtKB-ID:
FHR5_HUMAN
UniprotKB:
Q9BXR6
UniParc:
UPI0000043814
EMBL:
AF295327,
BC111773
Ensembl:
ENSG00000134389
KO:
hsa:81494
|
| Nucleutide sequences |
EMBL-CDS:
AAI11774.1,
AAK15619.1
Ensembl_TRS:
ENST00000256785
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256785
RefSeq:
NP_110414.1,
XP_011508322.1
|
| Others |
UniRef100:
UniRef100_Q9BXR6
UniRef90:
UniRef90_Q9BXR6
UniRef50:
UniRef50_Q9BXR6
UniGene:
Hs.282594
CCDS:
CCDS1387.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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