PF3D7_0512700 - orotate phosphoribosyltransferase-BMKCloudï½ç¾è¿å®¢äº

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812941 PF3D7_0512700

基因描述

Type	Description
Definition	orotate phosphoribosyltransferase

研究结论

Date	Results	Publications
2016-02-27 10:16:00	Unique amino acids were revealed in the PfOPRTase active sites and specific protein-protein interactions.	25945715
2014-10-04 10:52:00	Studied the multienzyme complex formation of human malaria parasite Plasmodium falciparum (P. falciparum) orotate phosphoribosyltransferase (OPRT) and orotidine 5'-monophosphate decarboxylase (OMPDC).	24507637
2014-02-22 11:46:00	OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes. Despite their tight binding to the targets, the inhibitors did not kill cultured P. falciparum	24158442
2010-01-21 00:00:00	The result suggests that the OPRT-OMPDC enzyme complex might have kinetic benefits and thermal stability significantly different from the monofunctional enzyme.	19800871
2010-01-21 00:00:00	cloning and expression analysis of dihydroorotase, orotate phosphoribosyltransferase, and OMP decarboxylase	15571277

名称对应

Type	IDs
Synonymous	PFE0630c
Gene	UniProtKB-ID: Q8I3Y0_PLAF7 UniprotKB: Q8I3Y0 UniParc: UPI0000081C6D EMBL: AL844504 EnsemblGenome: PF3D7_0512700 KO: pfa:PF3D7_0512700
Nucleutide sequences	EMBL-CDS: CAD51491.1 Gene_ORFName: PF3D7_0512700
Protein sequencees	RefSeq: XP_001351684.1
Others	UniRef100: UniRef100_A0A2I0BUC2 UniRef90: UniRef90_A0A2P9GG51 UniRef50: UniRef50_A0A1A8W9V0

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
25945715	Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Acta Crystallogr F Struct Biol Commun Shiva Kumar , Kalyanaraman Krishnamoorthy , Devaraja G Mudeppa , Pradipsinh K Rathod	2015-05-01	-
24507637	A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase. Asian Pac J Trop Med Waranya Imprasittichail , Sittiruk Roytrakul , Sudaratana R Krungkrai , Jerapan Krungkrail	2014-03-01	-
24158442	Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem Yong Zhang , Gary B Evans , Keith Clinch , Douglas R Crump , Lawrence D Harris , Richard F G FrÃ¶hlich , Peter C Tyler , Keith Z Hazleton , MarÃa B Cassera , Vern L Schramm	2013-11-29	-
19800871	Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum. Biochem. Biophys. Res. Commun. Panan Kanchanaphum , Jerapan Krungkrai	2009-12-11	PF10_0225, PfOPRT
15683248	A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization. Biochemistry Sudaratana R Krungkrai , Brian J DelFraino , Jeffrey A Smiley , Phisit Prapunwattana , Toshihide Mitamura , Toshihiro Horii , Jerapan Krungkrai	2005-02-08	PF10_0225
15571277	Cloning and expression of malarial pyrimidine enzymes. Nucleosides Nucleotides Nucleic Acids R I Christopherson , O Cinquin , M Shojaei , D Kuehn , R I Menz	2004-10-01	PF14_0697, PfOPRT
15003844	Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile. Mol. Biochem. Parasitol. Sudaratana R Krungkrai , Sayaka Aoki , Nirianne Marie Q Palacpac , Dan Sato , Toshihide Mitamura , Jerapan Krungkrai , Toshihiro Horii	2004-04-01	-
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature N Hall , A Pain , M Berriman , C Churcher , B Harris , D Harris , K Mungall , S Bowman , R Atkin , S Baker , A Barron , K Brooks , C O Buckee , C Burrows , I Cherevach , C Chillingworth , T Chillingworth , Z Christodoulou , L Clark , R Clark , C Corton , A Cronin , R Davies , P Davis , P Dear , F Dearden , J Doggett , T Feltwell , A Goble , I Goodhead , R Gwilliam , N Hamlin , Z Hance , D Harper , H Hauser , T Hornsby , S Holroyd , P Horrocks , S Humphray , K Jagels , K D James , D Johnson , A Kerhornou , A Knights , B Konfortov , S Kyes , N Larke , D Lawson , N Lennard , A Line , M Maddison , J McLean , P Mooney , S Moule , L Murphy , K Oliver , D Ormond , C Price , M A Quail , E Rabbinowitsch , M-A Rajandream , S Rutter , K M Rutherford , M Sanders , M Simmonds , K Seeger , S Sharp , R Smith , R Squares , S Squares , K Stevens , K Taylor , A Tivey , L Unwin , S Whitehead , J Woodward , J E Sulston , A Craig , C Newbold , B G Barrell	2002-10-03	MAL7P1.110, MAL7P1.113, MAL7P1.104, MAL7P1.93, MAL7P1.94, PF07_0005, PF07_0014, MAL7P1.162, MAL7P1.164, MAL7P1.4, MAL7P1.69, MAL7P1.73, MAL7P1.147, MAL7P1.150, MAL7P1.151, MAL7P1.161, MAL7P1.75, MAL7P1.81, MAL7P1.86, PF07_0021, PF07_0023, PF07_0027, PF07_0040, MAL7P1.137, MAL7P1.139, MAL7P1.145, PF07_0046, PF07_0047, PF07_0054, PF07_0057, PF07_0059, PF07_0062, PF07_0065, PF07_0070, PF07_0071, PfCDPK4, PF07_0073, PF07_0079, PF07_0080, PF07_0085, PF07_0086, PF07_0088, PF07_0091, PF07_0098, MAL7P1.130, PF07_0103, PF07_0105, PF07_0112, PF07_0115, PF07_0117, PF07_0123, MAL7P1.118, MAL7P1.12, MAL7P1.122, MAL7P1.20, PfCRT, MAL7P1.37, MAL7P1.38, MAL8P1.13, MAL8P1.131, MAL8P1.23, MAL8P1.12, MAL8P1.125, MAL8P1.128, MAL8P1.110, PF08_0055, PF08_0056, PF08_0059, PF08_0069, FeSOD, PF08_0075, PF08_0076, PF08_0084, PF08_0085, PF08_0096, PF08_0108, PF08_0126, PF08_0129, PF08_0132, PF08_0136b, MAL8P1.48, MAL8P1.51, MAL8P1.37, MAL8P1.40, MAL8P1.43, MAL8P1.108, MAL8P1.140, MAL8P1.3, MAL8P1.31, MAL8P1.32, MAL8P1.33, MAL8P1.76, MAL8P1.78, MAL8P1.83, MAL8P1.9, PF08_0006, PF08_0009, PF08_0011, PF08_0014

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