| Type | Description |
|---|---|
| Definition | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
| Date | Results | Publications |
|---|---|---|
| 2017-03-11 10:18:00 | Innovative scaffolds with novel modes of action, improved efficacy and acceptable physiochemical/pharmacokinetic properties were computationally identified as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria. | 27650666 |
| 2014-03-15 11:58:00 | Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative. | 24032981 |
| 2010-06-14 12:09:00 | A three-dimensional model of the malarial drug target protein PfDXR was generated, and validated using structure-checking programs and protein docking studies. | 20214634 |
| 2010-04-12 12:17:00 | These data indicate that deoxyxylulose 5-phosphate reductoisomerase is required for intraerythrocytic development of Plasmodium falciparum. | 20018214 |
| Type | IDs |
|---|---|
| Synonymous | PF14_0641 |
| Gene |
UniProtKB-ID:
DXR_PLAF7,
A0A144A2T4_PLAF7
UniprotKB:
Q8IKG4,
A0A144A2T4
UniParc:
UPI0000032784
EMBL:
LN999946,
AE014187
EnsemblGenome:
PF3D7_1467300
KO:
pfa:PF3D7_1467300
|
| Nucleutide sequences |
EMBL-CDS:
AAN37254.1,
CZU00370.1
Gene_ORFName:
PF14_0641,
PF3D7_1467300
EnsemblGenome_TRS:
CZU00370
|
| Protein sequencees |
EnsemblGenome_PRO:
CZU00370
RefSeq:
XP_001348815.1
|
| Others |
UniRef100:
UniRef100_Q8IKG4
UniRef90:
UniRef90_Q8IKG4
UniRef50:
UniRef50_Q8IKG4
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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