PF3D7_1446200 - M17 leucyl aminopeptidase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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812021 PF3D7_1446200

基因描述

Type	Description
Definition	M17 leucyl aminopeptidase

研究结论

Date	Results	Publications
2018-05-19 11:53:00	The evaluation of a highly selective inhibitor of PfA-M1, over PfA-M17, active on Plasmodium parasites in vitro and in vivo, highlights the relevance of PfA-M1 in the biological development of the parasite as well as in the list of promising anti-malarial targets to be considered in combination with current or future anti-malarial drugs.	28934959
2010-05-10 11:16:00	detailed understanding of the PfA-M1 and PfA-M17 active sites now permits a rational approach in the development of a unique class of two-target and/or combination antimalarial therapy.	20133789
2010-01-21 00:00:00	When this enzyme is the target of bestatin inhibition, its overexpression in malaria cells may lead to a reduced sensitivity to the inhibitor.	16286469

名称对应

Type	IDs
Synonymous	PF14_0439
Gene	UniProtKB-ID: Q8IL11_PLAF7 UniprotKB: Q8IL11 UniParc: UPI0000084B63 EMBL: LN999946 EnsemblGenome: PF3D7_1446200 KO: pfa:PF3D7_1446200
Nucleutide sequences	EMBL-CDS: CZU00157.1 Gene_ORFName: PF3D7_1446200
Protein sequencees	RefSeq: XP_001348613.1
Others	UniRef100: UniRef100_A0A2I0C1H8 UniRef90: UniRef90_A0A024V0B1 UniRef50: UniRef50_A0A024V0B1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
28934959	Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo. Malar. J. Lotfi Bounaadja , Marjorie Schmitt , SÃ©bastien Albrecht , Elisabeth Mouray , CÃ©line Tarnus , Isabelle Florent	2017-09-21	-
20133789	Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases. Proc. Natl. Acad. Sci. U.S.A. Sheena McGowan , Christine A Oellig , Woldeamanuel A Birru , Tom T Caradoc-Davies , Colin M Stack , Jonathan Lowther , Tina Skinner-Adams , Artur Mucha , Pawel Kafarski , Jolanta Grembecka , Katharine R Trenholme , Ashley M Buckle , Donald L Gardiner , John P Dalton , James C Whisstock	2010-02-09	LAP, MAL13P1.56
17107951	Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. J Biol Chem Colin M Stack , Jonathan Lowther , Eithne Cunningham , Sheila Donnelly , Donald L Gardiner , Katharine R Trenholme , Tina S Skinner-Adams , Franka Teuscher , Jolanta Grembecka , Artur Mucha , Pawel Kafarski , Linda Lua , Angus Bell , John P Dalton	2007-01-19	-
16286469	Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. J Biol Chem Donald L Gardiner , Katharine R Trenholme , Tina S Skinner-Adams , Colin M Stack , John P Dalton	2006-01-20	-
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum. Nature Malcolm J Gardner , Neil Hall , Eula Fung , Owen White , Matthew Berriman , Richard W Hyman , Jane M Carlton , Arnab Pain , Karen E Nelson , Sharen Bowman , Ian T Paulsen , Keith James , Jonathan A Eisen , Kim Rutherford , Steven L Salzberg , Alister Craig , Sue Kyes , Man-Suen Chan , Vishvanath Nene , Shamira J Shallom , Bernard Suh , Jeremy Peterson , Sam Angiuoli , Mihaela Pertea , Jonathan Allen , Jeremy Selengut , Daniel Haft , Michael W Mather , Akhil B Vaidya , David M A Martin , Alan H Fairlamb , Martin J Fraunholz , David S Roos , Stuart A Ralph , Geoffrey I McFadden , Leda M Cummings , G Mani Subramanian , Chris Mungall , J Craig Venter , Daniel J Carucci , Stephen L Hoffman , Chris Newbold , Ronald W Davis , Claire M Fraser , Bart Barrell	2002-10-03	-
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature N Hall , A Pain , M Berriman , C Churcher , B Harris , D Harris , K Mungall , S Bowman , R Atkin , S Baker , A Barron , K Brooks , C O Buckee , C Burrows , I Cherevach , C Chillingworth , T Chillingworth , Z Christodoulou , L Clark , R Clark , C Corton , A Cronin , R Davies , P Davis , P Dear , F Dearden , J Doggett , T Feltwell , A Goble , I Goodhead , R Gwilliam , N Hamlin , Z Hance , D Harper , H Hauser , T Hornsby , S Holroyd , P Horrocks , S Humphray , K Jagels , K D James , D Johnson , A Kerhornou , A Knights , B Konfortov , S Kyes , N Larke , D Lawson , N Lennard , A Line , M Maddison , J McLean , P Mooney , S Moule , L Murphy , K Oliver , D Ormond , C Price , M A Quail , E Rabbinowitsch , M-A Rajandream , S Rutter , K M Rutherford , M Sanders , M Simmonds , K Seeger , S Sharp , R Smith , R Squares , S Squares , K Stevens , K Taylor , A Tivey , L Unwin , S Whitehead , J Woodward , J E Sulston , A Craig , C Newbold , B G Barrell	2002-10-03	MAL7P1.110, MAL7P1.113, MAL7P1.104, MAL7P1.93, MAL7P1.94, PF07_0005, PF07_0014, MAL7P1.162, MAL7P1.164, MAL7P1.4, MAL7P1.69, MAL7P1.73, MAL7P1.147, MAL7P1.150, MAL7P1.151, MAL7P1.161, MAL7P1.75, MAL7P1.81, MAL7P1.86, PF07_0021, PF07_0023, PF07_0027, PF07_0040, MAL7P1.137, MAL7P1.139, MAL7P1.145, PF07_0046, PF07_0047, PF07_0054, PF07_0057, PF07_0059, PF07_0062, PF07_0065, PF07_0070, PF07_0071, PfCDPK4, PF07_0073, PF07_0079, PF07_0080, PF07_0085, PF07_0086, PF07_0088, PF07_0091, PF07_0098, MAL7P1.130, PF07_0103, PF07_0105, PF07_0112, PF07_0115, PF07_0117, PF07_0123, MAL7P1.118, MAL7P1.12, MAL7P1.122, MAL7P1.20, PfCRT, MAL7P1.37, MAL7P1.38, MAL8P1.13, MAL8P1.131, MAL8P1.23, MAL8P1.12, MAL8P1.125, MAL8P1.128, MAL8P1.110, PF08_0055, PF08_0056, PF08_0059, PF08_0069, FeSOD, PF08_0075, PF08_0076, PF08_0084, PF08_0085, PF08_0096, PF08_0108, PF08_0126, PF08_0129, PF08_0132, PF08_0136b, MAL8P1.48, MAL8P1.51, MAL8P1.37, MAL8P1.40, MAL8P1.43, MAL8P1.108, MAL8P1.140, MAL8P1.3, MAL8P1.31, MAL8P1.32, MAL8P1.33, MAL8P1.76, MAL8P1.78, MAL8P1.83, MAL8P1.9, PF08_0006, PF08_0009, PF08_0011, PF08_0014

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