PF3D7_1129000 - spermidine synthase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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810848 PF3D7_1129000

基因描述

Type	Description
Definition	spermidine synthase

研究结论

Date	Results	Publications
2015-12-05 11:10:00	The complexes with the aniline compounds and BIPA revealed a new mode of ligand binding to PfSpdS.	25760598
2010-01-21 00:00:00	characterization of the structural and mechanistic properties of the PfSpdSyn as well as the elucidation of the active site residues involved in substrate, product, and inhibitor interactions	17196392
2010-01-21 00:00:00	Results show that binding of dcAdoMet to pfSPDS stabilizes the flexible gatekeeper loop of spermidine synthase and affects the conformation of the active-site amino acid residues, preparing the protein for binding of the second substrate.	17822713

名称对应

Type	IDs
Synonymous	PF11_0301
Gene	UniProtKB-ID: Q8II73_PLAF7 UniprotKB: Q8II73 UniParc: UPI0000084F27 EMBL: LN999945 EnsemblGenome: PF3D7_1129000 KO: pfa:PF3D7_1129000
Nucleutide sequences	EMBL-CDS: CZT98952.1 Gene_ORFName: PF3D7_1129000
Protein sequencees	RefSeq: XP_001347972.1
Others	UniRef100: UniRef100_W7JTL4 UniRef90: UniRef90_Q9NFS5 UniRef50: UniRef50_A0A1A8W1Y8

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
25760598	Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design. Acta Crystallogr. D Biol. Crystallogr. Janina Sprenger , Bo Svensson , Jenny HÃ¥lander , Jannette Carey , Lo Persson , Salam Al-Karadaghi	2015-03-01	PF11_0301
17822713	Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J. Mol. Biol. Veronica Tamu Dufe , Wei Qiu , Ingrid B MÃ¼ller , Raymond Hui , Rolf D Walter , Salam Al-Karadaghi	2007-10-12	PF11_0301
17196392	Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase. Bioorg. Med. Chem. Pieter B Burger , Lyn-Marie Birkholtz , Fourie Joubert , Nashya Haider , Rolf D Walter , Abraham I Louw	2007-02-15	PF11_0301
15913804	The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme. Mol. Biochem. Parasitol. Nashya Haider , Marie-Luise Eschbach , Suzana de Souza Dias , Tim-Wolf Gilberger , Rolf D Walter , Kai LÃ¼ersen	2005-08-01	PF11_0301
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature N Hall , A Pain , M Berriman , C Churcher , B Harris , D Harris , K Mungall , S Bowman , R Atkin , S Baker , A Barron , K Brooks , C O Buckee , C Burrows , I Cherevach , C Chillingworth , T Chillingworth , Z Christodoulou , L Clark , R Clark , C Corton , A Cronin , R Davies , P Davis , P Dear , F Dearden , J Doggett , T Feltwell , A Goble , I Goodhead , R Gwilliam , N Hamlin , Z Hance , D Harper , H Hauser , T Hornsby , S Holroyd , P Horrocks , S Humphray , K Jagels , K D James , D Johnson , A Kerhornou , A Knights , B Konfortov , S Kyes , N Larke , D Lawson , N Lennard , A Line , M Maddison , J McLean , P Mooney , S Moule , L Murphy , K Oliver , D Ormond , C Price , M A Quail , E Rabbinowitsch , M-A Rajandream , S Rutter , K M Rutherford , M Sanders , M Simmonds , K Seeger , S Sharp , R Smith , R Squares , S Squares , K Stevens , K Taylor , A Tivey , L Unwin , S Whitehead , J Woodward , J E Sulston , A Craig , C Newbold , B G Barrell	2002-10-03	MAL7P1.110, MAL7P1.113, MAL7P1.104, MAL7P1.93, MAL7P1.94, PF07_0005, PF07_0014, MAL7P1.162, MAL7P1.164, MAL7P1.4, MAL7P1.69, MAL7P1.73, MAL7P1.147, MAL7P1.150, MAL7P1.151, MAL7P1.161, MAL7P1.75, MAL7P1.81, MAL7P1.86, PF07_0021, PF07_0023, PF07_0027, PF07_0040, MAL7P1.137, MAL7P1.139, MAL7P1.145, PF07_0046, PF07_0047, PF07_0054, PF07_0057, PF07_0059, PF07_0062, PF07_0065, PF07_0070, PF07_0071, PfCDPK4, PF07_0073, PF07_0079, PF07_0080, PF07_0085, PF07_0086, PF07_0088, PF07_0091, PF07_0098, MAL7P1.130, PF07_0103, PF07_0105, PF07_0112, PF07_0115, PF07_0117, PF07_0123, MAL7P1.118, MAL7P1.12, MAL7P1.122, MAL7P1.20, PfCRT, MAL7P1.37, MAL7P1.38, MAL8P1.13, MAL8P1.131, MAL8P1.23, MAL8P1.12, MAL8P1.125, MAL8P1.128, MAL8P1.110, PF08_0055, PF08_0056, PF08_0059, PF08_0069, FeSOD, PF08_0075, PF08_0076, PF08_0084, PF08_0085, PF08_0096, PF08_0108, PF08_0126, PF08_0129, PF08_0132, PF08_0136b, MAL8P1.48, MAL8P1.51, MAL8P1.37, MAL8P1.40, MAL8P1.43, MAL8P1.108, MAL8P1.140, MAL8P1.3, MAL8P1.31, MAL8P1.32, MAL8P1.33, MAL8P1.76, MAL8P1.78, MAL8P1.83, MAL8P1.9, PF08_0006, PF08_0009, PF08_0011, PF08_0014
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum. Nature Malcolm J Gardner , Neil Hall , Eula Fung , Owen White , Matthew Berriman , Richard W Hyman , Jane M Carlton , Arnab Pain , Karen E Nelson , Sharen Bowman , Ian T Paulsen , Keith James , Jonathan A Eisen , Kim Rutherford , Steven L Salzberg , Alister Craig , Sue Kyes , Man-Suen Chan , Vishvanath Nene , Shamira J Shallom , Bernard Suh , Jeremy Peterson , Sam Angiuoli , Mihaela Pertea , Jonathan Allen , Jeremy Selengut , Daniel Haft , Michael W Mather , Akhil B Vaidya , David M A Martin , Alan H Fairlamb , Martin J Fraunholz , David S Roos , Stuart A Ralph , Geoffrey I McFadden , Leda M Cummings , G Mani Subramanian , Chris Mungall , J Craig Venter , Daniel J Carucci , Stephen L Hoffman , Chris Newbold , Ronald W Davis , Claire M Fraser , Bart Barrell	2002-10-03	-

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