| Type | Description |
|---|---|
| Definition | pumilio RNA-binding family member 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:04:00 | Pum1 and Pum2 achieve these two complementary aspects of pluripotency by forming a negative interregulatory feedback loop that directly regulates at least 1,486 mRNAs. Pum1 and Pum2 regulate target mRNAs not only by repressing translation, but also by promoting translation and enhancing or reducing mRNA stability of different target mRNAs. | 32198202 |
| 2020-04-18 11:19:00 | Norad is the preferred RNA target of PUMILIO2 (PUM2) in mouse tissues and, upon loss of Norad, PUM2 hyperactively represses key genes required for mitosis and mitochondrial function. Accordingly, enforced Pum2 expression fully phenocopies Norad deletion, resulting in rapid-onset aging-associated phenotypes. | 30735131 |
| 2020-04-18 10:07:00 | Pum1 and Pum2 regulate mouse body and organ size by post-transcriptional repression of the cell cycle inhibitor Cdkn1b. | 30811992 |
| 2020-03-28 10:44:00 | These results reveal that Pum2 shapes axonal transcriptomes by preventing the transport of Pumilio-binding elements -containing mRNAs into axons | 31606248 |
| 2019-06-29 12:07:00 | A PUM2-mediated layer of post-transcriptional regulation links altered Mff translation to mitochondrial dynamics and mitophagy, thereby mediating age-related mitochondrial dysfunctions. | 30642763 |
| Type | IDs |
|---|---|
| Synonymous | 5730503J23Rik, Pumm2 |
| Gene |
UniProtKB-ID:
PUM2_MOUSE,
Q3UR91_MOUSE,
Q3TQ29_MOUSE
UniprotKB:
Q80U58,
Q3UR91,
Q3TQ29
UniParc:
UPI0000236D73,
UPI000000B253,
UPI00005B1FFB,
UPI00005AC0A8,
UPI0000021982
EMBL:
AC110382,
AF315590,
AC134245,
AK163964,
BC013765,
AK122225,
AK141682,
AY027917,
BC041773
Ensembl:
ENSMUSG00000020594
KO:
mmu:80913
|
| Nucleutide sequences |
EMBL-CDS:
BAC65507.1,
AAH13765.1,
AAG31805.1,
AAH41773.1,
AAK21966.1,
BAE24797.1,
BAE37556.1
Ensembl_TRS:
ENSMUST00000168361,
ENSMUST00000178015,
ENSMUST00000169089,
ENSMUST00000163569,
ENSMUST00000111122,
ENSMUST00000111123,
ENSMUST00000020915
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000128292,
ENSMUSP00000131074,
ENSMUSP00000137020,
ENSMUSP00000132122,
ENSMUSP00000106752,
ENSMUSP00000106751,
ENSMUSP00000020915
RefSeq:
XP_036013578.1,
NP_109648.2,
XP_030102862.1,
XP_036013573.1,
XP_017170746.1,
XP_017170745.1,
XP_036013579.1,
XP_030102860.1,
XP_017170747.1,
XP_017170744.1,
XP_006515346.1,
XP_030102856.1,
NP_001153691.1,
XP_030102854.1,
XP_006515348.1,
XP_006515343.1,
XP_030102857.1,
NP_001297448.1,
XP_006515340.1,
XP_030102861.1,
NP_001153693.1,
XP_030102855.1,
XP_006515341.1,
XP_030102859.1,
XP_036013575.1,
XP_006515347.1,
XP_017170748.1,
NP_001153694.1,
XP_036013580.1,
XP_036013576.1,
NP_001153692.1,
XP_030102863.1,
XP_017170743.1,
XP_036013577.1,
XP_030102853.1,
XP_006515342.1,
XP_006515345.1,
XP_036013574.1
|
| Others |
UniRef100:
UniRef100_Q80U58,
UniRef100_Q3TQ29,
UniRef100_Q3UR91
UniRef90:
UniRef90_Q8TB72-3,
UniRef90_Q80U58,
UniRef90_Q3TQ29
UniRef50:
UniRef50_Q80U58-2,
UniRef50_Q8TB72
UniGene:
Mm.341243
CCDS:
CCDS49026.1,
CCDS25802.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员