| Type | Description |
|---|---|
| Definition | hydroxycarboxylic acid receptor 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:38:00 | Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease. | 32093510 |
| 2020-08-22 15:29:00 | Niacin Ameliorates Hepatic Steatosis by Inhibiting Lipogenesis Via a GPR109A-Mediated Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. | 31858105 |
| 2020-07-18 10:37:00 | The results of this study indicate that GPR109a does not play a critical role in intestinal homeostasis in a model of type 1 diabetes or in the development of diabetic nephropathy. | 32068460 |
| 2020-04-04 12:32:00 | These results indicate that during aging, GPR109A modulates de novo lipid accumulation in liver and adipose tissue, and its dysregulation can lead to age-associated obesity and hepatic steatosis. | 30659164 |
| 2019-11-02 11:27:00 | The Gpr109a receptor-mediated pathway contributed significantly to niacin mediated salutary effect. Further studies showed improvement in markers of cellular energetics and attenuation of inflammatory response with niacin treatment. In conclusion, Gpr109a-dependent signalling is important in restoring cellular energetics and immunometabolism following hemorrhagic shock. | 30625381 |
| Type | IDs |
|---|---|
| Synonymous | Gpr109a, Gpr109b, HM74, Niacr1, PUMA-G, Pumag, mHM74b |
| Gene |
UniProtKB-ID:
HCAR2_MOUSE,
Q0VBA6_MOUSE
UniprotKB:
Q9EP66,
Q0VBA6
UniParc:
UPI00000252D4
EMBL:
AJ300198,
KU285441,
BC120715,
AK150795,
AJ300199,
BC125296
Ensembl:
ENSMUSG00000045502
KO:
mmu:80885
|
| Nucleutide sequences |
EMBL-CDS:
CAC17790.1,
BAE29858.1,
CAC17791.1,
APT70323.1,
AAI25297.1,
AAI20716.1
Ensembl_TRS:
ENSMUST00000057145
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000054104
RefSeq:
NP_109626.1
|
| Others |
UniRef100:
UniRef100_Q9EP66
UniRef90:
UniRef90_Q9EP66
UniRef50:
UniRef50_Q9EP66
UniGene:
Mm.440567,
Mm.486809
CCDS:
CCDS19668.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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