| Type | Description |
|---|---|
| Definition | Nedd4 family interacting protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 11:30:00 | We found that in addition to influencing catalytic activities, the WW domain linker regions in NEDD4-1 and WWP2 can impact product distribution, including the degree of polyubiquitination and Lys-48 versus Lys-63 linkages. We show that allosteric activation by NDFIP1 or engineered ubiquitin variants is largely mediated by relief of WW domain linker autoinhibition. | 31578285 |
| 2018-11-03 10:05:00 | we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells | 29333944 |
| 2017-02-04 12:38:00 | the expression of Ndfipl reduced expression of a-synuclein. In conclusion, Ndfipl plays a significant role in protecting SH-SY5Y cells in in vitro Parkinson's disease models. | 27173227 |
| 2016-04-16 12:07:00 | Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin secretion. These effects were associated with an increase in the cellular content of JunB, a potent inhibitor of ER stress and apoptosis. | 26319551 |
| 2016-04-02 11:59:00 | Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi. | 26363003 |
| Type | IDs |
|---|---|
| Synonymous | N4WBP5 |
| Gene |
UniProtKB-ID:
NFIP1_HUMAN
UniprotKB:
Q9BT67
UniParc:
UPI000003B0DE,
UPI0000037796
EMBL:
AB097010,
BC004317,
AK315481,
AY192728,
AK075524,
AL832993,
CH471062,
AB097037,
AK075495
Ensembl:
ENSG00000131507
KO:
hsa:80762
|
| Nucleutide sequences |
EMBL-CDS:
EAW61889.1,
BAC11652.1,
BAC77390.1,
AAP13460.1,
AAH04317.1,
BAC77363.1,
EAW61888.1,
BAG37865.1,
CAH56294.1,
BAC11670.1
Gene_ORFName:
PSEC0192,
PSEC0223
Ensembl_TRS:
ENST00000253814
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000253814
RefSeq:
NP_085048.1
|
| Others |
UniRef100:
UniRef100_Q9BT67
UniRef90:
UniRef90_Q8R0W6
UniRef50:
UniRef50_Q8R0W6
UniGene:
Hs.9788,
Hs.653510
CCDS:
CCDS4273.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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