| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase 4A2 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:28:00 | A FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2. | 32733084 |
| 2020-10-24 14:11:00 | Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. | 32788364 |
| 2019-09-07 11:17:00 | study identified a critical role for PRL2 phosphatase in the proliferation and survival of human T-ALL cells; demonstrated that PRL2 is important for the leukemogenic potential of oncogenic NOTCH1 in vivo | 27872499 |
| 2019-05-04 11:41:00 | altered PRL-2 expression leads to metabolic reprogramming of the cells. These findings uncover a magnesium-sensitive mechanism controlling PRL expression, which plays a role in cellular bioenergetics | 30718434 |
| 2018-06-23 11:41:00 | identified a critical role for PRL2 phosphatase in the proliferation and survival of human AML cells. Further, we demonstrated that PRL2 is essential for the leukemogenic potential of AML1-ETO9a in vivo | 28220038 |
| Type | IDs |
|---|---|
| Synonymous | HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b |
| Gene |
UniProtKB-ID:
TP4A2_HUMAN
UniprotKB:
Q12974
UniParc:
UPI000006FF2E,
UPI00006C0364,
UPI00006C0362,
UPI0000022FCA
EMBL:
L48722,
U48297,
U14603,
AF208850,
AK297280,
L39000,
CH471059,
AL136115,
L48723,
L48937,
BC070182,
AK292703
Ensembl:
ENSG00000184007
KO:
hsa:8073
|
| Nucleutide sequences |
EMBL-CDS:
BAG59751.1,
AAB40598.1,
EAX07578.1,
BAF85392.1,
AAB42170.1,
EAX07583.1,
AAB59575.1,
EAX07579.1,
AAF64264.1,
AAB39331.1,
AAA90979.1,
AAH70182.1,
AAB42169.1,
EAX07582.1
Gene_ORFName:
BM-008
Ensembl_TRS:
ENST00000602725,
ENST00000602683,
ENST00000457805,
ENST00000649841,
ENST00000647444
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000493688,
ENSP00000497092,
ENSP00000409260,
ENSP00000473490,
ENSP00000473259
RefSeq:
NP_001356788.1,
NP_001182030.1,
NP_001182029.1,
NP_001356787.1,
NP_536316.1,
NP_001356789.1
|
| Others |
UniRef100:
UniRef100_Q12974
UniRef90:
UniRef90_Q12974
UniRef50:
UniRef50_Q12974
UniGene:
Hs.470477,
Hs.713025
CCDS:
CCDS59193.1,
CCDS53292.1,
CCDS348.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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