| Type | Description |
|---|---|
| Definition | cullin 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 11:42:00 | E4orf6 triggers Cullin5 neddylation, which activates the CRL5 E3 ligase for p53 degradation | 31301771 |
| 2020-05-16 11:55:00 | BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. | 31387940 |
| 2020-02-29 12:22:00 | work identifies the essential role of CUL5- and SOCS3-mediated integrin beta1 turnover in controlling small-cell lung cancer metastasis, which might have therapeutic implications. | 30688657 |
| 2020-02-29 11:31:00 | Accumulation of Noxa caused by depletion of CRL5 components was responsible for re-sensitization to CDK9 inhibitor, but not MCL1 inhibitor. Discovery of a novel role of CRL5 in apoptosis and resistance to multiple types of anticancer agents suggests the potential to improve combination treatments | 31294695 |
| 2020-02-29 11:10:00 | REVIEW: current knowledge on CRL-5, its activation by the UBE2F-SAG, its regulation of various signaling pathways via substrate degradation, and its implications in human cancers | 31898233 |
| Type | IDs |
|---|---|
| Synonymous | CUL-5, VACM-1, VACM1 |
| Gene |
UniProtKB-ID:
CUL5_HUMAN
UniprotKB:
Q93034
UniParc:
UPI00001380B0
EMBL:
AF327710,
CH471065,
AK292575,
AF017061,
X81882,
BC063306
Ensembl:
ENSG00000166266
KO:
hsa:8065
|
| Nucleutide sequences |
EMBL-CDS:
BAF85264.1,
AAB70253.1,
CAA57465.1,
AAK07472.1,
AAH63306.1,
EAW67102.1
Ensembl_TRS:
ENST00000393094,
ENST00000531427
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000435376,
ENSP00000376808
RefSeq:
NP_003469.2,
XP_016873852.1,
XP_016873854.1,
XP_016873853.1,
XP_005271739.1,
XP_011541315.1
|
| Others |
UniRef100:
UniRef100_Q93034
UniRef90:
UniRef90_Q93034
UniRef50:
UniRef50_Q93034
UniGene:
Hs.440320
CCDS:
CCDS31668.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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