| Type | Description |
|---|---|
| Definition | Coenzyme A synthase |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:45:00 | CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in vitro. | 32828275 |
| 2020-06-20 12:16:00 | Study identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was consistently elevated in radioresistant human rectal cancers. This observation was validated in independent patient cohorts and further confirmed in colorectal cancer cell lines. COASY protein directly interacted with the PI3K regulatory subunit PI3K-P85alpha, which increased AKT and mTOR phosphorylation, enhancing cell survival. | 31704889 |
| 2019-03-30 11:19:00 | Loss of function variants in COASY are associated with lethal pontocerebellar hypoplasia and arthrogryposis. | 30143804 |
| 2018-05-19 11:24:00 | The recruitment of COASY inhibits CBP-mediated TPX2 acetylation, promoting TPX2 degradation for mitotic exit. | 29531224 |
| 2018-04-21 10:12:00 | The COASY protein contains a mitochondrial localization signal, a regulatory region and a domain for each of the two catalytic kinase domains: adenyl transferase and dephospho CoA | 27021474 |
| Type | IDs |
|---|---|
| Synonymous | DPCK, NBIA6, NBP, PCH12, PPAT, UKR1, pOV-2 |
| Gene |
UniProtKB-ID:
COASY_HUMAN
UniprotKB:
Q13057
UniParc:
UPI000006F293,
UPI00018131ED
EMBL:
CH471152,
AK075415,
AF208536,
BT007168,
AY094602,
BC067254,
BC020985,
AF453478,
U18919,
AC067852,
BC006354,
AK314076,
AK297153
Ensembl:
ENSG00000068120
KO:
hsa:80347
|
| Nucleutide sequences |
EMBL-CDS:
AAH67254.1,
BAG59652.1,
AAH06354.1,
AAM19996.1,
AAH20985.1,
AAF87955.1,
EAW60840.1,
AAA69699.1,
AAL50813.1,
BAG36775.1,
AAP35832.1
Gene_ORFName:
PSEC0106
Ensembl_TRS:
ENST00000393818,
ENST00000590958,
ENST00000421097
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000393564,
ENSP00000377406,
ENSP00000464814
RefSeq:
XP_006722179.1,
NP_001035997.2,
NP_079509.5,
XP_011523602.1,
NP_001035994.1
|
| Others |
UniRef100:
UniRef100_Q13057
UniRef90:
UniRef90_Q13057
UniRef50:
UniRef50_Q13057
UniGene:
Hs.296422,
Hs.742262
CCDS:
CCDS11429.1,
CCDS45685.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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