| Type | Description |
|---|---|
| Definition | DDB1 and CUL4 associated factor 11 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:52:00 | WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes. | 32839090 |
| 2020-11-21 13:30:00 | TFEB activates Nrf2 by repressing its E3 ubiquitin ligase DCAF11 and promoting phosphorylation of p62. | 31586112 |
| 2019-07-27 12:15:00 | results support a model in which the activation of the TNF-alpha/NF-kappaB axis contributes to an increase in CRL4B(DCAF)(11) activity and a decrease in p21(Cip1) protein levels, thereby controlling cell cycle progression in human osteosarcoma cells. | 29377600 |
| 2018-09-08 12:01:00 | Here, the authors demonstrated that CUL4B forms an E3 ligase with RBX1 (RING-box 1), DDB1 (DNA damage binding protein 1), and DCAF11 (DDB1 and CUL4 associated factor 11) that promotes the ubiquitination of p21(Cip1) and regulates cell cycle progression in human osteosarcoma cells. | 28446751 |
| 2017-08-19 12:04:00 | CRL4(WDR23) is required for efficient histone mRNA 3' end processing to produce mature histone mRNAs for translation. CRL4(WDR23) binds and ubiquitylates SLBP in vitro and in vivo, and this modification activates SLBP function in histone mRNA 3' end processing without affecting its protein levels. | 27203182 |
| Type | IDs |
|---|---|
| Synonymous | GL014, PRO2389, WDR23 |
| Gene |
UniProtKB-ID:
DCA11_HUMAN,
B3KSW2_HUMAN,
Q59GN6_HUMAN
UniprotKB:
Q8TEB1,
B3KSW2,
Q59GN6
UniParc:
UPI000000CC14,
UPI00004F6B69,
UPI000000CBCE,
UPI0000073AB2,
UPI00003E5DF3
EMBL:
AF130070,
AL136295,
BX161405,
CH471078,
BC008858,
AK074296,
AK094478,
AL833831,
AF267858,
BX247970,
AK027223,
BC067132,
AB209073,
AK057636
Ensembl:
ENSG00000284796,
ENSG00000100897
KO:
hsa:80344
|
| Nucleutide sequences |
EMBL-CDS:
EAW66110.1,
AAH08858.2,
CAD61885.1,
EAW66111.1,
BAB85041.1,
BAB15698.1,
EAW66113.1,
CAD62308.1,
BAG51945.1,
EAW66112.1,
CAD38691.1,
AAH67132.1,
EAW66114.1,
AAG44727.1,
AAG35498.1,
BAG52874.1,
BAD92310.1
Gene_ORFName:
PRO2389,
GL014
Ensembl_TRS:
ENST00000559115,
ENST00000396936,
ENST00000646568,
ENST00000446197,
ENST00000646524,
ENST00000644566,
ENST00000642239,
ENST00000396941
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000452898,
ENSP00000380142,
ENSP00000494282,
ENSP00000415556,
ENSP00000493711,
ENSP00000380146,
ENSP00000495415,
ENSP00000495416
RefSeq:
NP_001156956.1,
NP_852002.1,
NP_079506.3
|
| Others |
UniRef100:
UniRef100_Q8TEB1,
UniRef100_B3KSW2,
UniRef100_Q59GN6
UniRef90:
UniRef90_Q8TEB1,
UniRef90_A0A5G2RH85,
UniRef90_B3KSW2
UniRef50:
UniRef50_B3KSW2,
UniRef50_Q8TEB1
UniGene:
Hs.525251
CCDS:
CCDS9610.1,
CCDS41929.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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