| Type | Description |
|---|---|
| Definition | coiled-coil domain containing 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 11:01:00 | we propose CCDC6 as a biomarker of drugs sensitivity for MPMs. In case of MPMs expressing low levels of CCDC6 the addition of olaparib to cisplatinum and pemetrexed is expected to be highly beneficial. In case of MPMs expressing normal CCDC6 levels the sensitivity to olaparib can be restored by the addition of P5091. | 31447003 |
| 2019-11-09 12:11:00 | Results demonstrate that CCDC6 is a direct target of miR-146b which downregulates CCDC6 expression in papillary thyroid cancer (PTC). Also, CCDC6 expression correlates with clinicopathological parameters and exerts significant diagnostic and prognostic value in patients with PTC. | 30503553 |
| 2019-06-15 10:54:00 | The identification of two clusters of patients based on CCDC6 and USP7 expession can possibly indicate the use of drugs. | 30786932 |
| 2017-07-29 12:43:00 | FGFR inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2-CCDC6 fusions. | 27216979 |
| 2016-12-17 12:06:00 | Our findings nevertheless suggest that CCDC6-RET fusions identified by multiplex testing are potential targets for nintedanib therapy. | 26787234 |
| Type | IDs |
|---|---|
| Synonymous | D10S170, H4, PTC, TPC, TST1 |
| Gene |
UniProtKB-ID:
CCDC6_HUMAN,
Q05CP8_HUMAN
UniprotKB:
Q16204,
Q05CP8
UniParc:
UPI0000D4996C,
UPI000035B25A
EMBL:
S72869,
AC060231,
BC064391,
AK292593,
CH471083,
BC036757,
BC022284,
M31213,
AC023904
Ensembl:
ENSG00000108091
KO:
hsa:8030
|
| Nucleutide sequences |
EMBL-CDS:
AAC60637.1,
EAW54196.1,
AAH36757.2,
AAA36524.1,
AAH64391.1,
BAF85282.1,
AAH22284.1
Ensembl_TRS:
ENST00000263102
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263102
RefSeq:
NP_005427.2
|
| Others |
UniRef100:
UniRef100_Q16204,
UniRef100_Q05CP8
UniRef90:
UniRef90_Q05CP8,
UniRef90_Q16204
UniRef50:
UniRef50_Q05CP8,
UniRef50_Q16204
UniGene:
Hs.591360
CCDS:
CCDS7257.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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