| Type | Description |
|---|---|
| Definition | MLLT10 histone lysine methyltransferase DOT1L cofactor |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:22:00 | MLLT10 in benign and malignant hematopoiesis. | 32569758 |
| 2020-04-11 12:32:00 | the oligomerization ability of the DOT1L-AF10 complex is essential for MLL1-AF10's leukemogenic function | 31527241 |
| 2018-12-22 11:01:00 | In vitro, the overexpression of MLLT10 promoted colorectal cancer (CRC) cell migration and invasion, while after MLLT10 was knocked down, the opposite results were observed. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT. | 30102091 |
| 2017-05-20 11:44:00 | In a retroviral transduction/transplantation mouse model, mice transplanted with MLL/AF10(OM-LZ) cells harboring PTPN11(wt) developed myelomonocytic leukemia. Those transplanted with cells harboring PTPN11(G503A) -induced monocytic leukemia in a shorter latency. Adding PTPN11(G503A) to MLL/AF10 affected cell proliferation, chemo-resistance, differentiation, in vivo BM recruitment/clonal expansion and faster progression. | 27859216 |
| 2017-05-20 11:03:00 | Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women | 26480920 |
| Type | IDs |
|---|---|
| Synonymous | AF10 |
| Gene |
UniProtKB-ID:
AF10_HUMAN,
Q6N002_HUMAN,
Q59EQ6_HUMAN
UniprotKB:
P55197,
Q6N002,
Q59EQ6
UniParc:
UPI0000140022,
UPI00004F6E0B,
UPI00001F8FF7,
UPI000012564D,
UPI00004286CD,
UPI00001BDBC2
EMBL:
AL359697,
BC094844,
AL357372,
AL161799,
AB209755,
BC129946,
BX640774,
U13948,
BC080577,
AY598745,
AL358780
Ensembl:
ENSG00000078403
KO:
hsa:8028
|
| Nucleutide sequences |
EMBL-CDS:
AAH80577.1,
AAT47519.1,
AAA79972.1,
CAE45872.1,
BAD92992.1
Ensembl_TRS:
ENST00000631589,
ENST00000621220,
ENST00000307729,
ENST00000377100,
ENST00000652497,
ENST00000377059,
ENST00000377072,
ENST00000377091
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000366258,
ENSP00000307411,
ENSP00000366295,
ENSP00000366272,
ENSP00000488569,
ENSP00000484335,
ENSP00000366304,
ENSP00000498595
RefSeq:
XP_024303960.1,
XP_024303974.1,
XP_024303961.1,
XP_024303959.1,
NP_001182559.1,
XP_024303958.1,
XP_024303965.1,
NP_001182556.1,
XP_024303951.1,
XP_024303947.1,
XP_024303970.1,
XP_024303967.1,
XP_024303971.1,
XP_024303968.1,
NP_001182557.1,
XP_024303949.1,
NP_001311225.1,
XP_024303948.1,
XP_024303962.1,
XP_024303952.1,
XP_024303966.1,
XP_024303955.1,
NP_004632.1,
XP_024303956.1,
XP_024303969.1,
XP_024303973.1,
NP_001182555.1,
NP_001311226.1,
XP_024303963.1,
XP_024303972.1,
XP_024303950.1,
XP_024303954.1
|
| Others |
UniRef100:
UniRef100_Q6N002,
UniRef100_P55197,
UniRef100_Q59EQ6
UniRef90:
UniRef90_Q6N002,
UniRef90_P55197,
UniRef90_Q59EQ6
UniRef50:
UniRef50_A0A6I8RL18,
UniRef50_Q6N002,
UniRef50_P55197
UniGene:
Hs.30385
CCDS:
CCDS55707.1,
CCDS7135.1,
CCDS55706.1,
CCDS55708.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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