| Type | Description |
|---|---|
| Definition | chromosome X open reading frame 21 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:13:00 | Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis. | 31695690 |
| 2020-07-04 11:58:00 | identification of TASL as the component that links endolysosomal TLRs to the IRF5 transcription factor via SLC15A4 provides a mechanistic explanation for the involvement of these proteins in systemic lupus erythematosus | 32433612 |
| 2019-07-06 12:06:00 | Through combined genetic, in silico, in vitro, and ex vivo approaches, study defines CXorf21, a gene of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the Xp21.2 systemic lupus erythematosus association and demonstrates that CXorf21 is an IFN-response gene and that the sexual dimorphism in expression is magnified by immunological challenge. | 31092820 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TASL_HUMAN
UniprotKB:
Q9HAI6
UniParc:
UPI000006D5C7
EMBL:
AK021639,
BC020611
Ensembl:
ENSG00000120280
KO:
hsa:80231
|
| Nucleutide sequences |
EMBL-CDS:
AAH20611.1,
BAB13860.1
Ensembl_TRS:
ENST00000378962
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000368245
RefSeq:
NP_079435.1
|
| Others |
UniRef100:
UniRef100_Q9HAI6
UniRef90:
UniRef90_Q9HAI6
UniRef50:
UniRef50_Q9HAI6
UniGene:
Hs.665009
CCDS:
CCDS14224.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32433612 |
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. Nature Leonhard X Heinz , JangEun Lee , Utkarsh Kapoor , Felix Kartnig , Vitaly Sedlyarov , Konstantinos Papakostas , Adrian César-Razquin , Patrick Essletzbichler , Ulrich Goldmann , Adrijana Stefanovic , Johannes W Bigenzahn , Stefania Scorzoni , Mattia D Pizzagalli , Ariel Bensimon , André C Müller , F James King , Jun Li , Enrico Girardi , M Lamine Mbow , Charles E Whitehurst , Manuele Rebsamen , Giulio Superti-Furga |
2020-05-01 | - |
| 31092820 |
Nat Commun Christopher A Odhams , Amy L Roberts , Susan K Vester , Carolina S T Duarte , Charlie T Beales , Alexander J Clarke , Sonja Lindinger , Samuel J Daffern , Antonino Zito , Lingyan Chen , Leonardo L Jones , Lora Boteva , David L Morris , Kerrin S Small , Michelle M A Fernando , Deborah S Cunninghame Graham , Timothy J Vyse |
2019-05-15 | - |
| 31695690 |
Front Immunol Valerie M Harris , Kristi A Koelsch , Biji T Kurien , Isaac T W Harley , Jonathan D Wren , John B Harley , R Hal Scofield |
2019-01-01 | - |
| 31001245 |
Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21. Front Immunol Valerie M Harris , Isaac T W Harley , Biji T Kurien , Kristi A Koelsch , Robert Hal Scofield |
2019-01-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 18029348 |
Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics Laurent Barbe , Emma Lundberg , Per Oksvold , Anna Stenius , Erland Lewin , Erik Björling , Anna Asplund , Fredrik Pontén , Hjalmar Brismar , Mathias Uhlén , Helene Andersson-Svahn |
2008-03-01 | - |
| 17207965 |
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics Philippe Lamesch , Ning Li , Stuart Milstein , Changyu Fan , Tong Hao , Gabor Szabo , Zhenjun Hu , Kavitha Venkatesan , Graeme Bethel , Paul Martin , Jane Rogers , Stephanie Lawlor , Stuart McLaren , Amélie Dricot , Heather Borick , Michael E Cusick , Jean Vandenhaute , Ian Dunham , David E Hill , Marc Vidal |
2007-03-01 |
GNPDA1,
CTAGE4,
BCL2L11,
PIGK,
TIMM23,
NPIPA5,
CST8,
AP1M2,
COX17,
TIMM23B,
SNX29P1,
IL18BP,
RWDD2B,
TSSC4,
UPK1A-AS1,
ARPC5,
ARPC3,
TSPAN5,
TSPAN3,
TSPAN1,
PPIF,
CTDSP2,
NAMPT,
PDZK1IP1,
DHRS9,
RBM7,
MPHOSPH6,
DHRS2,
MPZL2,
GPA33,
CALCOCO2,
SPRY3,
SPRY1,
RAMP3,
TRAIP,
DNAJA2,
IKZF1,
CRISP3,
SIRPB1,
CNPY2,
B3GNT3,
WARS2,
NPM3,
CDO1,
CACNG3,
TUBB4B,
CEPT1,
PEMT,
WFDC2,
NSA2,
EMG1,
TIMM17A,
PPIE,
HAX1,
CIB2,
DCTN2,
RPP38,
SLC35A1,
IFI44,
CXCL13,
SIVA1,
MRPL28,
CENPA,
MAB21L2,
RAD51AP1,
MTX2,
CGRRF1,
DCTN6,
B3GNT2,
CLDN16,
PNMA2,
KLRA1P,
SRSF10,
ARPP21,
STARD10,
CGA,
EDDM3A,
CFHR3,
GPR83,
RAB10,
CPSF4,
RUNDC3A,
COPS8,
C11orf58,
CCDC85B,
GLIPR1,
KLK11,
SNRNP27,
LIAS,
LILRA2,
SNRNP35,
CYB561D2,
ESM1,
WDR5,
BTN2A1,
HHLA3,
BVES,
KLK8,
MRPL3
|
| 16344560 |
Genome Res. Kouichi Kimura , Ai Wakamatsu , Yutaka Suzuki , Toshio Ota , Tetsuo Nishikawa , Riu Yamashita , Jun-ichi Yamamoto , Mitsuo Sekine , Katsuki Tsuritani , Hiroyuki Wakaguri , Shizuko Ishii , Tomoyasu Sugiyama , Kaoru Saito , Yuko Isono , Ryotaro Irie , Norihiro Kushida , Takahiro Yoneyama , Rie Otsuka , Katsuhiro Kanda , Takahide Yokoi , Hiroshi Kondo , Masako Wagatsuma , Katsuji Murakawa , Shinichi Ishida , Tadashi Ishibashi , Asako Takahashi-Fujii , Tomoo Tanase , Keiichi Nagai , Hisashi Kikuchi , Kenta Nakai , Takao Isogai , Sumio Sugano |
2006-01-01 |
Nefm,
MED6,
CDH2,
PDZK1P1,
DDTL,
ABI1,
GNPDA1,
GTF2IP4,
ZSCAN30,
SRA1,
TMEM170B,
HOTAIR,
FAM86JP,
LOC100126784,
C8orf88,
LOC100128006,
RAB28P5,
MYHAS,
CDC42P3,
LOC100128979,
LOC100128993,
KTN1-AS1,
LOC100129083,
LOC100129204,
TOPORS-AS1,
LINC00484,
ZNF37BP,
FAM47E,
MRVI1-AS1,
ZNF737,
LOC100130075,
MAPT-IT1,
MIR124-2HG,
LINC00861,
LOC100130238,
LOC100130357,
PARD6G-AS1,
LOC100130547,
NFYC-AS1,
EFCAB10,
LOC100130798,
SBK3,
LOC100130849,
LOC100130872,
LOC100130880,
LOC100130987,
LOC100131047,
LINC01135,
CKMT2-AS1,
ZBTB20-AS1,
WDR86-AS1,
CCDC183-AS1,
SNAP25-AS1,
NEMP2,
ZNF503-AS2,
MIR181A1HG,
DBIL5P,
HDAC6,
MZF1-AS1,
ARMCX4,
LINC00271,
ZNF717,
LOC100132057,
LOC100132111,
CALML3-AS1,
NDUFA6-AS1,
FRG1HP,
FCGR1CP,
GXYLT1P3,
GOLGA8F,
DCAF13P3,
IPO5P1,
MSC-AS1,
SMIM9,
FAM66A,
CD24,
UXT-AS1,
JHDM1D-AS1,
UBE2Q2P2,
TEN1,
JMJD7,
PLA2G4B,
LINC00930,
PDCD6IP,
HECTD2-AS1,
ZFHX4-AS1,
FAR2P2,
LOC100233156,
PCED1B-AS1,
PIGK,
LOC100270746,
LOC100270804,
LINC00940,
ERVV-2,
MEF2B,
ZNRF2P2,
NFE2L3P2,
LINC00894,
BCDIN3D-AS1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
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|---|---|---|
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