| Type | Description |
|---|---|
| Definition | MUS81 structure-specific endonuclease subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 12:57:00 | we show that Mus81 is a regulator of ZEB1 and promotes metastasis in gastric cancer. Importantly, we demonstrate that the BRD4 inhibitor AZD5153 can potentially be used as an effective antimetastasis drug because of its effect on Mus81. | 31142662 |
| 2020-01-11 12:33:00 | In WRN-deficient cells, persistence of RAD51 correlates with elevated mitotic phosphorylation of MUS81 at Ser87, which is essential to prevent excessive mitotic abnormalities. Aberrant fork degradation, in the presence of a wild-type RAD51 axis, stimulates RAD51-mediated post-replicative repair and engagement of the MUS81 complex to limit genome instability and cell death. | 31114910 |
| 2019-10-19 11:30:00 | XPF and MUS81 merit further validation in prospective clinical trials as biomarkers that may predict clinical response of esophageal adenocarcinoma (EAC) to oxaliplatin-based chemotherapy. | 29739952 |
| 2019-08-24 10:09:00 | MUS81 is phosphorylated at serine 87 by the protein kinase CK2.CK2-mediated phosphorylation of MUS81 at serine 87 is an early mitotic event stimulated by mild replication stress.Regulated phosphorylation of MUS81 at serine 87 is essential to prevent accumulation of genome instability. | 29850896 |
| 2018-12-29 12:03:00 | Replication fork progression in BRCA2-deficient cells requires MUS81. MUS81 nucleolytic activity is required to activate compensatory DNA synthesis during mitosis and to resolve mitotic interlinks, thus facilitating chromosome segregation. | 28714477 |
| Type | IDs |
|---|---|
| Synonymous | SLX3 |
| Gene |
UniProtKB-ID:
MUS81_HUMAN,
Q53ES5_HUMAN
UniprotKB:
Q96NY9,
Q53ES5
UniParc:
UPI000050AA1D,
UPI000013ECCB
EMBL:
BC009999,
AK223564,
AF425646,
AK024665
Ensembl:
ENSG00000172732
KO:
hsa:80198
|
| Nucleutide sequences |
EMBL-CDS:
AAH09999.2,
BAB14953.1,
AAL28065.1,
BAD97284.1
Ensembl_TRS:
ENST00000308110
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000307853
RefSeq:
XP_011543571.1,
NP_079404.3,
NP_001337212.1,
XP_011543572.1
|
| Others |
UniRef100:
UniRef100_Q96NY9,
UniRef100_Q53ES5
UniRef90:
UniRef90_Q96NY9
UniRef50:
UniRef50_Q96NY9
UniGene:
Hs.288798
CCDS:
CCDS8115.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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