| Type | Description |
|---|---|
| Definition | splA/ryanodine receptor domain and SOCS box containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:31:00 | Cullin-5 Adaptor SPSB1 Controls NF-kappaB Activation Downstream of Multiple Signaling Pathways. | 32038638 |
| 2020-07-25 12:37:00 | Our results indicate that the paralogs Spsb1 and Spsb4, but not Spsb2 and Spsb3, can interact with and facilitate RevErbalpha ubiquitination and degradation and regulate circadian clock periodicity. | 31607207 |
| 2019-11-09 12:10:00 | SPSB1 plays a key role in ovarian cancer cell survival and proliferation. The data also reveal a novel mechanism of regulating p21 stability by SPSB1. | 30712944 |
| 2017-12-16 11:31:00 | EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1. | 28084329 |
| 2015-10-17 11:33:00 | SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain. | 26032413 |
| Type | IDs |
|---|---|
| Synonymous | SSB-1, SSB1 |
| Gene |
UniProtKB-ID:
SPSB1_HUMAN,
A0A024R4G8_HUMAN
UniprotKB:
Q96BD6,
A0A024R4G8
UniParc:
UPI000006D00B
EMBL:
AF403026,
BC015711,
AL358252,
AL008734,
CH471130,
AK026046,
AB209559,
BC005852
Ensembl:
ENSG00000171621
KO:
hsa:80176
|
| Nucleutide sequences |
EMBL-CDS:
EAW71617.1,
AAH15711.1,
BAD92796.1,
AAH05852.2,
BAB15335.1,
AAL57345.1,
EAW71618.1
Gene_ORFName:
hCG_22401
Ensembl_TRS:
ENST00000328089,
ENST00000377399,
ENST00000357898
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000330221,
ENSP00000350573,
ENSP00000366616
RefSeq:
NP_079382.2
|
| Others |
UniRef100:
UniRef100_Q96BD6
UniRef90:
UniRef90_Q96BD6
UniRef50:
UniRef50_Q96BD6
UniGene:
Hs.8261,
Hs.738680
CCDS:
CCDS102.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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