| Type | Description |
|---|---|
| Definition | CST telomere replication complex component 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 11:22:00 | CST functions in two distinct aspects of genome-wide DNA replication, namely, origin licensing and replisome assembly. CST interacts with additional replisome components, MCM and AND-1. | 30979824 |
| 2019-10-12 10:52:00 | Impaired interaction between CTC1(L1142H) :STN1 and DNA Pol-alpha results in increased telomerase recruitment to telomeres and further telomere elongation, revealing that C:S binding to DNA Pol-alpha is required to fully repress telomerase activity. | 29774655 |
| 2019-08-10 12:23:00 | Results show that disease-causing CTC1 mutations induce spontaneous chromosome breakage and severe chromosome fragmentation that are further elevated by replication stress, leading to global genome instabilities. | 29481669 |
| 2019-07-27 12:47:00 | Findings indicate the OB-fold domain contributes to efficient CST telomere replication complex component 1 (Ctc1) telomere localization and chromosome end maintenance. | 29228254 |
| 2019-02-02 12:26:00 | Studies indicate telomere-binding proteins CTC1-STN1-TEN1 (CST) dysfunction and mutation is associated with several genetic diseases and cancers [Review]. | 29293451 |
| Type | IDs |
|---|---|
| Synonymous | AAF-132, AAF132, C17orf68, CRMCC, tmp494178 |
| Gene |
UniProtKB-ID:
CTC1_HUMAN
UniprotKB:
Q2NKJ3
UniParc:
UPI000041A9A9,
UPI0000E59E0D
EMBL:
BC111783,
AL831955,
AK025823,
BC110373,
DQ451688,
AK091077,
BC026057,
AC135178
Ensembl:
ENSG00000178971
KO:
hsa:80169
|
| Nucleutide sequences |
EMBL-CDS:
AAI11784.1,
BAG52278.1,
BAB15247.1,
ABE02809.1,
CAD38600.1,
AAH26057.2,
AAI10374.1
Ensembl_TRS:
ENST00000651323,
ENST00000449476
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000498499,
ENSP00000396018
RefSeq:
XP_006721640.1,
XP_011522312.1,
XP_011522313.1,
NP_079375.3,
XP_006721641.1
|
| Others |
UniRef100:
UniRef100_Q2NKJ3
UniRef90:
UniRef90_Q2NKJ3
UniRef50:
UniRef50_Q2NKJ3
UniGene:
Hs.156055
CCDS:
CCDS42259.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员