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8001 GLRA3

8001

GLRA3

glycine receptor alpha 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition glycine receptor alpha 3

研究结论

Date Results Publications
2019-10-26 10:32:00 In this study, the association between the common rs10011025 variant in the GLRA3 locus, and albuminuria, was confirmed in 1259 independent Finnish individuals with type 1 diabetes (p = 0.0013), and meta-analysis of all Finnish individuals yielded a genome-wide significant association. 30120300
2019-05-25 11:46:00 Using quantitative photoactivated localisation microscopy the authors found that alpha-1 and alpha-3 containing glycine receptors display the same alpha3:beta2 stoichiometry and gephyrin binding. 28883437
2019-03-30 11:49:00 This study explores the roles of Tyr and Trp residues in the extracellular domains of the glycine receptor alpha 3 and shows that four such residues that have not been previously studied (Y24, Y58, W170, and Y197) contribute significantly to the function of the protein. 29947514
2017-07-08 10:37:00 X-ray crystal structure of human homopentameric GlyRalpha3 in complex with AM-3607, a potentiator of the same class with increased potency, and the agonist glycine, at 2.6-A resolution. 27991902
2017-05-13 13:43:00 data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts. 27382060

名称对应

Type IDs
Gene
UniProtKB-ID: GLRA3_HUMAN, Q9UPF3_HUMAN
UniprotKB: O75311, Q9UPF3
UniParc: UPI000007129A, UPI0000001C50, UPI000016B539
EMBL: U93917, AF017715, AF017724, AF017716, AF017718, AF017723, AF017720, AF017722, BC036086, AF018157, CH471056, AF017717, AF017721, AF017719
Ensembl: ENSG00000145451
KO: hsa:8001
Nucleutide sequences
EMBL-CDS: AAC39917.1, AAC39919.1, EAX04732.1, EAX04730.1, AAH36086.1, AAC39918.1
Ensembl_TRS: ENST00000340217, ENST00000274093
Protein sequencees
Ensembl_PRO: ENSP00000274093, ENSP00000345284
RefSeq: XP_016864119.1, XP_011530569.1, XP_011530570.1, NP_001036008.1, NP_006520.2
Others
UniRef100: UniRef100_A0A2I3NFP6, UniRef100_O75311
UniRef90: UniRef90_O75311
UniRef50: UniRef50_O75311
UniGene: Hs.413099
CCDS: CCDS3822.1, CCDS43283.1

全选

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